https://scholars.lib.ntu.edu.tw/handle/123456789/510415
標題: | High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis | 作者: | CHUN-TA HUANG LI-NA LEE CHAO-CHI HO CHIN-CHUNG SHU SHENG-YUAN RUAN Tsai Y.-J. JANN-YUAN WANG CHONG-JEN YU |
公開日期: | 2014 | 出版社: | W.B. Saunders Ltd | 卷: | 68 | 期: | 5 | 起(迄)頁: | 440-447 | 來源出版物: | Journal of Infection | 摘要: | Objectives: Comparisons of procalcitonin (PCT), C-reactive protein (CRP), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) would expand our knowledge of which biomarker is the best predictor for outcomes of patients with pulmonary tuberculosis (PTB). Methods: We prospectively enrolled 243 PTB patients, in whom PCT, CRP, and sTREM-1 measurement were performed to evaluate their prognostic value for 6-month mortality. Results: Serum PCT, CRP, and sTREM-1 levels on diagnosis of PTB were significantly higher in nonsurvivors (2.22±6.22 vs. 0.13±0.31ng/mL, P=0.043; 42.1±59.4 vs. 12.5±29.1mg/L, P=0.004; 332±362 vs. 128±98pg/mL, P=0.001, respectively) as compared with 6-month survivors. In multivariate Cox regression analysis, PCT ≧0.5ng/mL (hazard ratio 4.13, 95% CI, 1.99-8.58) and sTREM-1 ≧129pg/mL (hazard ratio 3.39, 95% CI, 1.52-7.58) remained independent mortality predictors. Serum PCT and sTREM-1 levels above the cutoffs were also associated with the presence of disseminated tuberculosis. Conclusions: Among PTB patients, higher PCT, CRP, and sTREM-1 levels are observed in nonsurvivors than in 6-month survivors. Serum levels of PCT and sTREM-1 over the cutoffs are independently associated with a poor outcome. In addition, higher PCT and sTREM-1 levels would raise the clinical suspicion of disseminated tuberculosis. ? 2014 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897959643&doi=10.1016%2fj.jinf.2013.12.012&partnerID=40&md5=bd980e8874e118089cd6d2981e5d1116 https://scholars.lib.ntu.edu.tw/handle/123456789/510415 |
ISSN: | 0163-4453 | DOI: | 10.1016/j.jinf.2013.12.012 | SDG/關鍵字: | biological marker; C reactive protein; procalcitonin; triggering receptor expressed on myeloid cells 1; C reactive protein; calcitonin; immunoglobulin receptor; membrane protein; procalcitonin; protein precursor; TREM1 protein, human; adult; area under the curve; article; clinical evaluation; controlled study; diagnostic test accuracy study; disease association; female; human; lung tuberculosis; major clinical study; male; miliary tuberculosis; mortality; outcome assessment; pleura effusion; predictive value; prognosis; prospective study; protein blood level; protein expression; receiver operating characteristic; sensitivity analysis; aged; blood; chemistry; middle aged; pathology; prognosis; serum; survival; Tuberculosis, Pulmonary; very elderly; young adult; Adult; Aged; Aged, 80 and over; C-Reactive Protein; Calcitonin; Female; Humans; Male; Membrane Glycoproteins; Middle Aged; Prognosis; Prospective Studies; Protein Precursors; Receptors, Immunologic; Serum; Survival Analysis; Tuberculosis, Pulmonary; Young Adult |
顯示於: | 醫學系 |
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