https://scholars.lib.ntu.edu.tw/handle/123456789/510924
標題: | An overweight or obese status in childhood predicts subclinical atherosclerosis and prehypertension/hypertension in young adults | 作者: | TA-CHEN SU Liao C.-C. KUO-LIONG CHIEN SANDY HUEY-JEN HSU Sung F.-C. |
公開日期: | 2014 | 卷: | 21 | 期: | 11 | 起(迄)頁: | 1170-1182 | 來源出版物: | Journal of Atherosclerosis and Thrombosis | 摘要: | Aim: The aim of this study, the YOung TAiwanese Cohort (YOTA) Study, was to investigate the relationship between a childhood overweight/obese status and young adult preclinical atherosclerosis, including assessments of the carotid intima-media thickness (CIMT) and prehypertension or hypertension.Methods: From among children who participated in the 1992-2000 mass urine screening program in Taiwan, we recruited 303 subjects with an elevated blood pressure (EBP) and 486 subjects with a normal BP in childhood during the period of 2006-2008. These 789 young adults received health check-ups for cardiovascular health, including examinations of blood and urine parameters, anthropometrics, BP and the CIMT, a subclinical cardiovascular risk index. Data analyses were used to evaluate the associated risks in both childhood and young adulthood.Results: The school students with a childhood overweight/obese status had a higher risk of prehypertension or hypertension, with a relative risk of 3.20 (1.40-7.33) for being overweight and 6.51 (3.3612.63) for being obese in young adulthood at an average age of 21. A childhood overweight/obese status also predicted a higher risk of having a thicker CIMT, with a relative risk of 2.82 (1.26-6.28) and 4.17 (2.21-7.85) for being overweight and obese in adulthood, respectively, after a mean follow-up of 8.5 years. The body mass index exhibited a consistent trend from childhood to adulthood, with an adjusted R square of 0.551. The participants who were not overweight/obese in childhood also demonstrated a higher risk of prehypertension or hypertension if they became overweight or obese in adulthood.Conclusions: This study highlights the importance of preventing and treating an overweight or obese status in childhood for the primary prevention of cardiovascular disease in adulthood. ? 2014, Japan Atherosclerosis Society. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510924 | ISSN: | 1340-3478 | DOI: | 10.5551/jat.25536 | SDG/關鍵字: | glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; biological marker; adult; arterial wall thickness; Article; B scan; blood sampling; body mass; cardiovascular risk; carotid atherosclerosis; childhood obesity; cholesterol blood level; common carotid artery; controlled study; diabetes mellitus; diastolic blood pressure; elevated blood pressure; female; follow up; human; internal carotid artery; major clinical study; male; mercury sphygmomanometer; prediction; prehypertension; questionnaire; R wave; systolic blood pressure; young adult; adolescent; arterial wall thickness; atherosclerosis; blood; child; cohort analysis; complication; hypertension; obesity; prehypertension; prognosis; Adolescent; Adult; Atherosclerosis; Biological Markers; Carotid Intima-Media Thickness; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Hypertension; Male; Obesity; Overweight; Prehypertension; Prognosis; Young Adult |
顯示於: | 醫學檢驗暨生物技術學系 |
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