https://scholars.lib.ntu.edu.tw/handle/123456789/511158
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li J. | en_US |
dc.contributor.author | Li W. | en_US |
dc.contributor.author | Niu J. | en_US |
dc.contributor.author | Song X. | en_US |
dc.contributor.author | Wu W. | en_US |
dc.contributor.author | Gong T. | en_US |
dc.contributor.author | Zheng R. | en_US |
dc.contributor.author | TIFFANY TING-FANG SHIH | en_US |
dc.contributor.author | Li W. | en_US |
dc.contributor.author | Zhou X.J. | en_US |
dc.creator | Li J.;Li W.;Niu J.;Song X.;Wu W.;Gong T.;Zheng R.;Tiffany Ting-Fang Shih;Li W.;Zhou X.J. | - |
dc.date.accessioned | 2020-08-06T07:51:42Z | - |
dc.date.available | 2020-08-06T07:51:42Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/511158 | - |
dc.description.abstract | Background: Acute myeloid leukemia (AML) features relatively low overall survival (OS). Intravoxel incoherent motion (IVIM) diffusion-weighted MRI separates tissue microcapillary perfusion and diffusivity and may have potential for helping to assess prognosis in infiltrated marrow disease apart from solid tumor. Thus, a study of overall survival would contribute to clarifying the value of IVIM for assessing long-term prognosis in AML. Purpose: To determine whether the IVIM-derived parameters of infiltrated bone marrow may be associated with OS in newly diagnosed AML. Materials and Methods: This prospective study enrolled participants with newly diagnosed AML between July 2014 to March 2016 consecutively. Participants underwent MRI of the lumbar spine by using an IVIM sequence. Participant clinical characteristics and OS were collected. The median of follow-up period was 20 months (range, 1–56 months). The IVIM parameters (pseudoperfusion fraction, f; diffusion coefficient, D; and pseudodiffusion coefficient, D*) were obtained. A nonparametric log-rank test was used to identify the threshold of IVIM parameters for OS. Univariable Kaplan-Meier and multivariable Cox proportional hazards regression analyses were performed to investigate prognostic significance of possible indicators. Results: Fifty-three participants (mean age, 42 years 6 17; 30 men) were evaluated. Nonparametric log-rank test results showed that the thresholds of f and D values for OS were 31.0% and 0.2 3 1023 mm2/sec, respectively. Univariable analyses indicated that high f value (.31.0%) and low D value (?0.2 3 1023 mm2/sec) were associated with shorter OS (P = .003 and .01, respectively). An f value greater than 31.0% (hazard ratio, 2.4; 95% confidence interval: 1.0, 5.6; P = .046) was associated with OS, independent of clinical confounders (age, karyotype, and white blood cell counts) in a multivariable analysis. Conclusion: Pseudoperfusion fraction and diffusion coefficient from intravoxel incoherent motion diffusion-weighted MRI may be viable prognosis predictors of newly diagnosed acute myeloid leukemia. ? RSNA, 2020. | - |
dc.relation.ispartof | Radiology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | acute myeloid leukemia; adolescent; adult; age; aged; Article; bone marrow; cancer prognosis; controlled study; diffusion weighted imaging; female; follow up; human; image analysis; intravoxel incoherent motion diffusion weighted imaging; karyotype; leukocyte count; lumbar spine; major clinical study; male; overall survival; priority journal; prospective study; acute myeloid leukemia; bone marrow; diagnostic imaging; diffusion weighted imaging; leukemic infiltration; middle aged; mortality; motion; pathology; predictive value; procedures; prognosis; survival rate; Adult; Bone Marrow; Diffusion Magnetic Resonance Imaging; Female; Humans; Leukemia, Myeloid, Acute; Leukemic Infiltration; Male; Middle Aged; Motion; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Rate | - |
dc.title | Intravoxel incoherent motion diffusion-weighted MRI of infiltrated marrow for predicting overall survival in newly diagnosed acute myeloid leukemia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1148/radiol.2020191693 | - |
dc.identifier.pmid | 32068504 | - |
dc.identifier.scopus | 2-s2.0-85082146760 | - |
dc.relation.pages | 155-161 | - |
dc.relation.journalvolume | 295 | - |
dc.relation.journalissue | 1 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.orcid | 0000-0002-3292-9688 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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