https://scholars.lib.ntu.edu.tw/handle/123456789/511404
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | MING-CHU CHANG | en_US |
dc.contributor.author | YU-TING CHANG | en_US |
dc.contributor.author | SHU-CHEN WEI | en_US |
dc.contributor.author | PO-CHIN LIANG | en_US |
dc.contributor.author | I-SHIOW JAN | en_US |
dc.contributor.author | Su Y.-N. | en_US |
dc.contributor.author | Kuo C.-H. | en_US |
dc.contributor.author | Wong J.-M. | en_US |
dc.date.accessioned | 2020-08-11T08:36:56Z | - |
dc.date.available | 2020-08-11T08:36:56Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1424-3903 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/511404 | - |
dc.description.abstract | Background/Aims: Variations and haplotypes of the chymotrypsin C (CTRC) gene in Chinese patients with chronic pancreatitis (CP) and control subjects with genotype-phenotype correlation were investigated. Methods: One hundred and twenty-six patients with CP were analyzed. The entire sequence of coding regions of exons 2, 3 and 7 and their neighboring intronic regions in introns 1, 2 and 6 of the CTRC gene were analyzed using PCR sequence-specific primers and direct sequencing. The exonic region of exon 7 and the neighboring intronic region of intron 6 were also analyzed in 90 geographically matched healthy control subjects. Results: In total, 4 novel variations were identified in exons 2, 3 and 7 in 3 CP patients. A total of 2.3% (3/126) of our CP patients carried variations of the CTRC gene. We also first identified six new intronic variations in intron 6 which had not been reported before. The GAGGGG, GAGGAG and GAGTAG haplotypes assembled by six locus intronic variations c.640-41/c.640-40/c.640-39/c.640-37/c.640-36/c.640-35 in intron 6 were associated with a significantly higher susceptibility risk of CP (OR 66.75, 37.00, and 9.37, respectively). Conclusion: Novel CTRC gene variations and haplotypes are associated with CP in a Chinese population. Copyright ? 2009 S. Karger AG, Basel and IAP. | - |
dc.relation.ispartof | Pancreatology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; article; Chinese; chronic pancreatitis; chymotrypsin C gene; coding; controlled study; disease association; exon; female; gene sequence; genetic association; genetic identification; genetic susceptibility; genetic variability; genotype phenotype correlation; haplotype; human; intron; major clinical study; male; polymerase chain reaction; priority journal; Taiwan | - |
dc.title | Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1159/000199437 | - |
dc.identifier.pmid | 19407484 | - |
dc.identifier.scopus | 2-s2.0-65449140633 | - |
dc.relation.pages | 287-292 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Medical Imaging-NTUHHC | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4896-7838 | - |
crisitem.author.orcid | 0000-0002-5912-3406 | - |
crisitem.author.orcid | 0000-0002-5017-5840 | - |
crisitem.author.orcid | 0000-0002-6674-2926 | - |
crisitem.author.orcid | 0000-0002-7936-5306 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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