https://scholars.lib.ntu.edu.tw/handle/123456789/511440
標題: | Adiponectin: A biomarker of obesity-induced insulin resistance in adipose tissue and beyond | 作者: | JIN-YING LU KUO-CHIN HUANG LIN-CHAU CHANG Huang Y.-S. Chi Y.-C. Su T.-C. CHI-LING CHEN WEI-SHIUNG YANG |
公開日期: | 2008 | 卷: | 15 | 期: | 5 | 起(迄)頁: | 565-576 | 來源出版物: | Journal of Biomedical Science | 摘要: | Adiponectin is one of the most thoroughly studied adipocytokines. Low plasma levels of adiponectin are found to associate with obesity, metabolic syndrome, diabetes and many other human diseases. From animal experiments and human studies, adiponectin has been shown to be a key regulator of insulin sensitivity. In this article, we review the evidence and propose that hypo-adiponectinemia is not a major cause of obesity. Instead, it is the result of obesity-induced insulin resistance in the adipose tissue. Hypo-adiponectinemia then mediates the metabolic effects of obesity on the other peripheral tissues, such as liver and skeletal muscle and may also exert some direct effects on end-organ damage. We propose that deciphering the molecular details governing the adiponectin gene expression and protein secretion will lead us to more comprehensive understanding of the mechanisms of insulin resistance in the adipose tissue and provide us new avenues for the therapeutic intervention of obesity and insulin resistance-related human disorders. ? 2008 National Science Council. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-51349167640&doi=10.1007%2fs11373-008-9261-z&partnerID=40&md5=4f96857536bfccba9f2d51b4b9e645dc https://scholars.lib.ntu.edu.tw/handle/123456789/511440 |
ISSN: | 1021-7770 | DOI: | 10.1007/s11373-008-9261-z | SDG/關鍵字: | adipocytokine; adiponectin; xenobiotic agent; adipose tissue; body weight; disease model; gene expression; human; insulin resistance; insulin sensitivity; liver; metabolism; molecular mechanics; nonhuman; nucleotide sequence; obesity; organ injury; priority journal; protein secretion; review; skeletal muscle; Adiponectin; Adipose Tissue; Biological Markers; Humans; Insulin Resistance; Obesity; Animalia |
顯示於: | 醫學系 |
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