https://scholars.lib.ntu.edu.tw/handle/123456789/511485
DC Field | Value | Language |
---|---|---|
dc.contributor.author | BANG-BIN CHEN | en_US |
dc.contributor.author | TIFFANY TING-FANG SHIH | en_US |
dc.date.accessioned | 2020-08-12T02:42:43Z | - |
dc.date.available | 2020-08-12T02:42:43Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/511485 | - |
dc.description.abstract | Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables tumor vascular physiology to be assessed. Within the tumor tissue, contrast agents (gadolinium chelates) extravasate from intravascular into the extravascular extracellular space (EES), which results in a signal increase on T1-weighted MRI. The rate of contrast agents extravasation to EES in the tumor tissue is determined by vessel leakiness and blood flow. Thus, the signal measured on DCE-MRI represents a combination of permeability and per-fusion. The semi-quantitative analysis is based on the calculation of heuristic parameters that can be extracted from signal intensity-time curves. These enhancing curves can also be deconvoluted by mathematical modeling to extract quantitative parameters that may reflect tumor perfusion, vascular volume, vessel permeability and angiogenesis. Because hepatocel-lular carcinoma (HCC) is a hypervascular tumor, many emerging therapies focused on the inhibition of angio-genesis. DCE-MRI combined with a pharmacokinetic model allows us to produce highly reproducible and reliable parametric maps of quantitative parameters in HCC. Successful therapies change quantitative parameters of DCE-MRI, which may be used as early indicators of tumor response to anti-angiogenesis agents that modulate tumor vasculature. In the setting of clinical trials, DCE-MRI may provide relevant clinical information on the pharmacodynamic and biologic effects of novel drugs, monitor treatment response and predict survival outcome in HCC patients. ? 2014 Baishideng Publishing Group Co., Limited. All rights reserved. | - |
dc.relation.ispartof | World Journal of Gastroenterology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | bevacizumab; biological marker; dexamethasone; floxuridine; sorafenib; sunitinib; thalidomide; vandetanib; vasculotropin; angiogenesis inhibitor; contrast medium; gadolinium pentetate; tumor marker; angiogenesis; article; blood vessel permeability; cancer specific survival; clinical trial (topic); computer assisted tomography; diagnostic imaging; disease course; dynamic contrast enhanced magnetic resonance imaging; experimental model; extravascular extracellular space; human; liver cell carcinoma; overall survival; quantitative analysis; radiodiagnosis; tissue perfusion; treatment response; tumor blood flow; tumor invasion; tumor microenvironment; tumor vascularization; vascular tumor; diagnostic use; image enhancement; liver; liver cell carcinoma; liver tumor; neovascularization (pathology); nuclear magnetic resonance imaging; pathology; perfusion; permeability; procedures; theoretical model; treatment outcome; Angiogenesis Inhibitors; Carcinoma, Hepatocellular; Clinical Trials as Topic; Contrast Media; Gadolinium DTPA; Humans; Image Enhancement; Liver; Liver Neoplasms; Magnetic Resonance Imaging; Models, Theoretical; Neovascularization, Pathologic; Perfusion; Permeability; Treatment Outcome; Tumor Markers, Biological | - |
dc.title | DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3748/wjg.v20.i12.3125 | - |
dc.identifier.pmid | 24695624 | - |
dc.identifier.scopus | 2-s2.0-84897003590 | - |
dc.relation.pages | 3125-3134 | - |
dc.relation.journalvolume | 20 | - |
dc.relation.journalissue | 12 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.orcid | 0000-0001-7058-1427 | - |
crisitem.author.orcid | 0000-0002-3292-9688 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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