https://scholars.lib.ntu.edu.tw/handle/123456789/512205
標題: | Selection of empirical antibiotics for health care-associated pneumonia via integration of pneumonia severity index and risk factors of drug-resistant pathogens | 作者: | Wang P.-H. HAO-CHIEN WANG Cheng S.-L. Chang H.-T. Laio C.-H. |
公開日期: | 2016 | 出版社: | Elsevier B.V. | 卷: | 115 | 期: | 5 | 起(迄)頁: | 356-363 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: The pneumonia severity index (PSI) both contains some risk factors of drug-resistant pathogens (DRPs) and represents the severity of health care-associated pneumonia. The aim of this study was to investigate whether the PSI could be used to predict DRPs and whether there were risk factors beyond the PSI. Methods: A retrospective observational study enrolled 530 patients with health care-associated pneumonia who were admitted from January 2005 to December 2010 in a tertiary care hospital. Results: A total of 206 patients (38.9%) had DRPs, of which the most common was Pseudomonas aeruginosa (24.3%). The incidence of DRPs increased with increasing PSI classes (6.7%, 25.5%, 36.9%, and 44.6% in PSI II, III, IV, and V, respectively). An analysis of the risk factors for DRPs by PSI classes revealed that wound care was associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in PSI V (p = 0.045). Nasogastric tube feeding (odds ratio, 3.88; 95% confidence interval, 1.75-8.60; p = 0.006), and bronchiectasis (odds ratio, 3.12; 95% confidence interval, 0.66-14.69; p = 0.007) were risk factors for DRPs in PSI III and IV. The area under the receiver operating characteristic curve progressed from 0.578 to 0.651 while integrating these risk factors with PSI classes. Conclusion: The findings suggested that PSI plus risk factors predicted the risk of DRPs. PSI II had a low risk of DRPs and could be treated as community-acquired pneumonia. Antibiotics of PSI III and IV with risk factors could be targeted DRPs. PSI V with wound care had a higher risk of MRSA, and empirical anti-MRSA antibiotics could be added. ? 2015. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928634722&doi=10.1016%2fj.jfma.2015.03.009&partnerID=40&md5=ab1e6a583b02b0d09d0fbe94339196da https://scholars.lib.ntu.edu.tw/handle/123456789/512205 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2015.03.009 | SDG/關鍵字: | antibiotic agent; antiinfective agent; adult; aged; algorithm; antibiotic resistance; antibiotic therapy; Article; bronchiectasis; female; health care associated pneumonia; hospital mortality; human; incidence; major clinical study; male; methicillin resistant Staphylococcus aureus; middle aged; nonhuman; nose feeding; observational study; Pneumonia Severity Index; Pseudomonas aeruginosa; retrospective study; risk factor; wound care; cross infection; odds ratio; Pneumonia, Bacterial; Pseudomonas Infections; receiver operating characteristic; severity of illness index; Staphylococcal Infections; Taiwan; tertiary care center; very elderly; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Bacterial; Female; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Odds Ratio; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Retrospective Studies; Risk Factors; ROC Curve; Severity of Illness Index; Staphylococcal Infections; Taiwan; Tertiary Care Centers |
顯示於: | 醫學系 |
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