https://scholars.lib.ntu.edu.tw/handle/123456789/512485
標題: | Interferon-gamma release assay and Rifampicin therapy for household contacts of tuberculosis | 作者: | JANN-YUAN WANG CHIN-CHUNG SHU Lee C.-H. CHONG-JEN YU LI-NA LEE PAN-CHYR YANG |
公開日期: | 2012 | 卷: | 64 | 期: | 3 | 起(迄)頁: | 291-298 | 來源出版物: | Journal of Infection | 摘要: | Objectives: Longitudinal studies in household contacts to identify subgroups at risk of active tuberculosis are lacking. Methods: Household contacts of pulmonary tuberculosis patients were prospectively enrolled to receive chest radiography, sputum studies, and T-SPOT.TB assay at initial visit. Repeat examinations every 6 months for 3 years, and 4-month rifampin preventive therapy for T-SPOT.TB-positive contacts were provided. We investigated factors predicting T-SPOT.TB-positivity and active pulmonary tuberculosis. Results: 583 contacts were enrolled with a follow-up duration of 20.7±9.4 months. 176 (30.2%) were T-SPOT.TB-positive initially and 32 (18.2%) of them received preventive therapy. Old age, living in the same room/house with the index case, the index case having a high smear grade (3+~4+) and pulmonary cavitation were associated with T-SPOT.TB-positivity. Active tuberculosis developed in 9T-SPOT.TB-positive contacts; risk factors included T-SPOT.TB-positivity without preventive therapy, living in the same room, and the index case being ?50 years or female. 108 (61.4%) T-SPOT.TB-positive contacts had repeat examinations. Forty-five had T-SPOT.TB reversion and none of them developed active tuberculosis. Conclusion: Household contacts who are T-SPOT.TB-positive and live in the same room as the index case are at risk of active tuberculosis and require preventive therapy and close follow-up. ? 2011 The British Infection Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856598035&doi=10.1016%2fj.jinf.2011.11.028&partnerID=40&md5=d99c7f675a606b0cfc7e9191b92bc7ee https://scholars.lib.ntu.edu.tw/handle/123456789/512485 |
ISSN: | 0163-4453 | DOI: | 10.1016/j.jinf.2011.11.028 | SDG/關鍵字: | rifampicin; adult; article; bacterium contamination; contact examination; controlled study; disease association; enzyme linked immunospot assay; female; follow up; human; infection prevention; infection risk; interferon gamma release assay; longitudinal study; lung cavitation; lung tuberculosis; major clinical study; male; nonhuman; outcome assessment; prediction; prospective study; risk assessment; risk factor; syndrome delineation; treatment duration; Adult; Aged; Antibiotics, Antitubercular; Contact Tracing; Family; Female; Follow-Up Studies; Humans; Interferon-gamma Release Tests; Male; Middle Aged; Prognosis; Rifampin; Risk Factors; Tuberculosis |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。