https://scholars.lib.ntu.edu.tw/handle/123456789/512489
標題: | Clinical characteristics and prognosis of nontuberculous mycobacterial lung disease with different radiographic patterns | 作者: | CHIN-CHUNG SHU Lee C.-H. CHIA-LIN HSU JANN-TAY WANG JANN-YUAN WANG CHONG-JEN YU LI-NA LEE |
公開日期: | 2011 | 卷: | 189 | 期: | 6 | 起(迄)頁: | 467-474 | 來源出版物: | Lung | 摘要: | Rationale: The clinical characteristics and prognostic impact of radiographic patterns of patients with nontuberculous mycobacterial lung disease (NTM-LD) are rarely evaluated. Design: Patients with NTM-LD from 2007 to 2009 in a single medical center in Taiwan were identified. Their radiographic patterns were reviewed and classified into cavitary, bronchiectatic, or consolidative. They were also compared to patients with cavitary pulmonary tuberculosis (TB-LD). Results: Of 481 NTM-LD patients identified, 62, 134, and 56 patients were categorized into cavitary, bronchiectatic, and consolidative groups, respectively. Compared with 180 TB-LD patients, cavitary NTM-LD had male predominance and was associated with higher grades of sputum acid-fast smear (3+ or 4+), prior pulmonary TB, and poor baseline pulmonary function. NTM-LD patients with consolidative pattern were likely to have underlying comorbidity, the highest blood leukocyte count and C-reactive protein, and lowest albumin. In all NTM-LD, the consolidative pattern was independently associated with poor prognosis for 6-month survival. Patients with cavitary Mycobacterium avium complex (MAC)-LD had worse 6-month survival than those with bronchiectatic pattern. Conclusion: In Taiwan, NTM-LD patients with consolidative pattern have the worst prognosis while patients with cavitary pattern have worse survival than those with bronchiectasis in MAC-LD. Because varying radiographic patterns represent different prognoses, understanding the characteristics of NTM-LD patients with different radiographic patterns complements clinical practice. ? 2011 Springer Science+Business Media, LLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-83555172642&doi=10.1007%2fs00408-011-9321-4&partnerID=40&md5=ceeb09369e9b18748b1f6b2b9b199ab4 https://scholars.lib.ntu.edu.tw/handle/123456789/512489 |
ISSN: | 0341-2040 | DOI: | 10.1007/s00408-011-9321-4 | SDG/關鍵字: | albumin; antimycobacterial agent; C reactive protein; adult; article; bronchiectatic nontuberculous mycobacterial lung disease; cavitary nontuberculous mycobacterial lung disease; clinical feature; comorbidity; consolidative nontuberculous mycobacterial lung disease; disease classification; female; human; leukocyte count; lung disease; lung function; lung tuberculosis; major clinical study; male; medical record review; Mycobacterium avium complex lung disease; Mycobacterium intracellulare avium; patient identification; priority journal; prognosis; radiodiagnosis; sputum smear; Taiwan; Adult; Aged; Aged, 80 and over; C-Reactive Protein; Female; Humans; Kaplan-Meier Estimate; Lung; Lung Diseases; Male; Middle Aged; Mycobacterium avium Complex; Mycobacterium Infections, Nontuberculous; Prognosis; Retrospective Studies; Serum Albumin; Tuberculosis, Pulmonary |
顯示於: | 醫學系 |
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