https://scholars.lib.ntu.edu.tw/handle/123456789/514062
Title: | Quantification of hepatic steatosis: A comparison of the accuracy among multiple magnetic resonance techniques | Authors: | CHIH-HORNG WU MING-CHIH HO YUNG-MING JENG CHAO-YU HSU PO-CHIN LIANG REY-HENG HU HONG-SHIEE LAI TIFFANY TING-FANG SHIH |
Issue Date: | 2014 | Journal Volume: | 29 | Journal Issue: | 4 | Start page/Pages: | 807-813 | Source: | Journal of Gastroenterology and Hepatology (Australia) | Abstract: | Background and Aim: Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are important diagnostic tools for the non-invasive assessment of hepatic steatosis (HS). This study was conducted to compare different magnetic resonance (MR) techniques and correlate the MR findings with histological and intracellular lipid density findings. Methods: In this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective study, 60 patients scheduled for liver resection were included in this study. Fat fraction in the non-tumorous liver parenchyma was estimated using double-echo MRI, triple-echo MRI (TE-MRI), and MRS. HS was defined by the histologic steatosis percentage (HSP), and intrahepatocellular triglyceride density (IHTGD) of the surgical specimen used as the reference standard. Imaging quantification results were evaluated using Pearson's correlation. Lin's concordance coefficient and Bland-Altman 95% limits of agreement were used to evaluate the concordance of IHTGDs estimated by the three MR techniques. The diagnostic performance was compared using receiver operating characteristic curve analysis. Results: HS assessed by TE-MRI and MRS had a stronger relationship with HS assessed by HSP and IHTGD. The TE-MRI method had the highest concordance correlation coefficients (ρ=0.881) and percentage (95%, 57/60) within the Bland-Altman 95% limits of agreement. Receiver operating characteristic curve analysis for diagnosing >5% HSP showed significantly larger area under the curve (0.9783) for TE-MRI than for double-echo MRI (0.8773, P=0.0121). Conclusions: Among the three MR techniques, TE-MRI and MRS may be the preferred techniques for non-invasive assessment of HS. ? 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514062 | ISSN: | 0815-9319 | DOI: | 10.1111/jgh.12451 | SDG/Keyword: | alanine aminotransferase; aspartate aminotransferase; cholesterol; ferritin; iron; triacylglycerol; adult; aged; area under the curve; article; density; diagnostic accuracy; double echo nuclear magnetic resonance imaging; fatty liver; female; ferritin blood level; health insurance; histopathology; human; intermethod comparison; iron binding capacity; iron blood level; liver fibrosis; liver parenchyma; liver resection; major clinical study; male; middle aged; nuclear magnetic resonance imaging; nuclear magnetic resonance spectroscopy; priority journal; prospective study; receiver operating characteristic; standard; triacylglycerol blood level; triple echo nuclear magnetic resonance imaging; very elderly; fatty liver; hepatic steatosis; magnetic resonance imaging; magnetic resonance spectroscopy; Adult; Aged; Aged, 80 and over; Fatty Liver; Female; Humans; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; ROC Curve; Sensitivity and Specificity; Triglycerides; Young Adult |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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