https://scholars.lib.ntu.edu.tw/handle/123456789/514187
標題: | Agyria-pachygyria: Clinical, neuroimaging, and neurophysiologic correlations | 作者: | Liang J.-S. WANG-TSO LEE Young C. STEVEN SHINN-FORNG PENG Shen Y.-Z. |
公開日期: | 2002 | 卷: | 27 | 期: | 3 | 起(迄)頁: | 171-176 | 來源出版物: | Pediatric Neurology | 摘要: | Agyria-pachygyria complex is a disorder of neuronal migration and organization. Patients suffer either motor or intellectual retardation. We report our experiences of 10 patients with agyria-pachygyria complex and evaluate their clinical features, electroencephalography, and evoked potentials. Of nine electroencephalography examinations, five patients demonstrated characteristically high-amplitude fast activity. One of nine patients had an abnormal brainstem auditory-evoked potential. Three of seven patients had abnormal goggled visual-evoked potential. Six patients received somatosensory-evoked potential examinations, and five of these were abnormal, including four with prolonged central conduction times. Of the 10 patients, eight survived with variable intellectual and motor retardation; two died of sepsis. Patients with grades 1-4 agyria-pachygyria had high incidences of somatosensory-evoked potential abnormalities and also suffered worse neurologic outcomes. Normal brainstem auditory-evoked potential but abnormal cortical somatosensory-evoked potential components and prolonged central conduction time in these patients indicate that agyria-pachygyria is a supratentorial disease. We conclude that somatosensory-evoked potential examination is supplemental to neuroimaging in predicting the neurologic prognosis of patients with agyria-pachygyria. ? 2002 by Elsevier Science Inc. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514187 | ISSN: | 0887-8994 | DOI: | 10.1016/S0887-8994(02)00401-0 | SDG/關鍵字: | adolescent; agyria; article; brain region; child; clinical article; clinical feature; controlled study; correlation analysis; disease severity; electroencephalography; evoked brain stem auditory response; evoked cortical response; evoked response; evoked somatosensory response; evoked visual response; female; human; imaging; intellectual impairment; male; motor retardation; nerve conduction; neurologic disease; neurophysiology; pachygyria; prediction; priority journal; prognosis; sepsis; survival; Adolescent; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Mental Retardation; Neural Conduction; Neurologic Examination; Neurons; Prognosis; Psychomotor Disorders; Reaction Time; Spasms, Infantile |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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