https://scholars.lib.ntu.edu.tw/handle/123456789/514397
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li C.-H. | en_US |
dc.contributor.author | Fan S.-P. | en_US |
dc.contributor.author | TA-FU CHEN | en_US |
dc.contributor.author | MING-JANG CHIU | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.contributor.author | CHIN-HSIEN LIN | en_US |
dc.creator | Li C.-H.;Fan S.-P.;Chen T.-F.;Chiu M.-J.;Ruoh-Fang Yen;Lin C.-H. | - |
dc.date.accessioned | 2020-09-23T06:22:11Z | - |
dc.date.available | 2020-09-23T06:22:11Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2162-3279 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514397 | - |
dc.description.abstract | Introduction: Frontal variant of Alzheimer's disease (fvAD) is a rare nonamnestic syndrome of Alzheimer's disease (AD). Differentiating it from behavior variant of frontotemporal dementia (bvFTD), which has implications for treatment responses and prognosis, remains a clinical challenge. Methods: Molecular neuroimaging and biofluid markers were performed for the index patient for accurate premortem diagnosis of fvAD. The clinical, neuroimaging, and biofluid characteristics of the patient were compared to those reported in previous studies of fvAD from 1999 to 2019. Results: A 66-year-old man presented with progressive executive dysfunction, personality and behavioral changes, and memory decline since age 59. He had no family history of neurodegenerative disorders. A stimulus-sensitive myoclonus was noted over his left upper extremity. Neuropsychological assessment revealed moderate dementia with a Mini-Mental State Exam score of 10/30 and compromised executive and memory performance. Brain imaging showed asymmetrical atrophy and hypometabolism over the right frontal and temporal areas, mimicking bvFTD. However, we observed increased tau depositions based on 18F-labeled T807 Tau PET in these areas and diffusely increased amyloid deposition based on 11C-labeled Pittsburgh compound B positron emission tomography (PET). Plasma biomarker measures indicated an AD profile with increased Aβ1-42 (18.66?pg/ml; cutoff: 16.42?pg/ml), Aβ1-42/Aβ1-40 ratio (0.45; cutoff: 0.30), total tau (29.78?pg/ml; cutoff: 23.89?pg/ml), and phosphorylated tau (4.11?pg/ml; cutoff: 3.08?pg/ml). These results supported a diagnosis of fvAD. Conclusions: Our results with asymmetrical presentations extend current knowledge about this rare AD variant. Application of biofluid and molecular imaging markers could assist in early, accurate diagnosis. ? 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. | - |
dc.relation.ispartof | Brain and Behavior | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amyloid beta protein; biological marker; cholinesterase; cyanocobalamin; dopamine; fluorodeoxyglucose; glucose; Pittsburgh compound B; tau protein; [2 [[2 [[[3 (4 chlorophenyl) 8 methyl 8 azabicyclo[3.2.1]oct 2 yl]methyl](2 mercaptoethyl)amino]ethyl]amino]ethanethiolato]oxotechnetium tc 99m; amyloid beta protein; tau protein; aged; aggressiveness; Alzheimer disease; amnesia; amygdala; apraxia; Article; behavior change; brain atrophy; Buschke selective reminding test; case report; cerebrospinal fluid analysis; clinical article; computer assisted tomography; frontal variant frontotemporal dementia; frontotemporal dementia; genetic analysis; high throughput sequencing; human; kidney function; language; lipid fingerprinting; male; memory disorder; Mini Mental State Examination; molecular imaging; myoclonus; neuroimaging; neuropsychological test; nuclear magnetic resonance imaging; perception; personality; pleocytosis; positron emission tomography; priority journal; single photon emission computed tomography; thyroid function; treatment response; Alzheimer disease; brain; diagnostic imaging; differential diagnosis; executive function; frontotemporal dementia; metabolism; middle aged; phosphorylation; physiology; procedures; Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Diagnosis, Differential; Executive Function; Frontotemporal Dementia; Humans; Male; Middle Aged; Neuroimaging; Neuropsychological Tests; Phosphorylation; Positron-Emission Tomography; tau Proteins | - |
dc.title | Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/brb3.1548 | - |
dc.identifier.pmid | 31989779 | - |
dc.identifier.scopus | 2-s2.0-85078777953 | - |
dc.relation.pages | e01548 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.orcid | 0000-0003-1988-6924 | - |
crisitem.author.orcid | 0000-0002-4158-4423 | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.orcid | 0000-0001-8566-7573 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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