https://scholars.lib.ntu.edu.tw/handle/123456789/514402
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Liao, Hung-Wei | en_US |
dc.contributor.author | SHUO-MENG WANG | en_US |
dc.contributor.author | CHIEH-KAI CHAN | en_US |
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.contributor.author | PO-CHIH LIN | en_US |
dc.contributor.author | Ho, Chen-Hsun | en_US |
dc.contributor.author | Liu, Yu-Chun | en_US |
dc.contributor.author | SHIH-CHIEH CHUEH | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | TAI-SHUAN LAI | en_US |
dc.contributor.author | SHAO-YU YANG | en_US |
dc.contributor.author | KAO-LANG LIU | en_US |
dc.contributor.author | CHIN-CHEN CHANG | en_US |
dc.contributor.author | Lee, B.-C. | en_US |
dc.contributor.author | KUO-HOW HUANG | en_US |
dc.contributor.author | LIAN-YU LIN | en_US |
dc.contributor.author | SHIH-CHENG LIAO | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.contributor.author | CHING-CHU LU | en_US |
dc.contributor.author | Er L.-K. | en_US |
dc.contributor.author | Hu, Y.-H. | en_US |
dc.contributor.author | Chang C.-H. | en_US |
dc.contributor.author | Wu, C.-H. | en_US |
dc.contributor.author | Tsai Y.-C. | en_US |
dc.contributor.author | Huang W.-C. | en_US |
dc.contributor.author | Chen Y.-Y. | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.creator | Liao H.-W.;Wang S.-M.;Chan C.-K.;Lin Y.-H.;Lin P.-C.;Ho C.-H.;Liu Y.-C.;Chueh J.S.;Wu V.-C.;Lai T.-S.;Yang S.-Y.;Liu K.-L.;Chang C.-C.;Lee B.-C.;Huang K.-H.;Lin L.-Y.;Liao S.-C.;Ruoh-Fang Yen;Lu C.-C.;Er L.-K.;Hu Y.-H.;Chang C.-H.;Wu C.-H.;Tsai Y.-C.;Chueh S.-C.J.;Huang W.-C.;Chen Y.-Y.;Wu K.-D. | - |
dc.date.accessioned | 2020-09-23T06:22:12Z | - |
dc.date.available | 2020-09-23T06:22:12Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2040-6223 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514402 | - |
dc.description.abstract | Background: In primary aldosteronism (PA), kidney function impairment could be concealed by relative hyperfiltration and emerge after adrenalectomy. We hypothesized transtubular gradient potassium gradient (TTKG), a kidney aldosterone bioactivity indicator, could correlate to end organ damage and forecast kidney function impairment after adrenalectomy. Methods: In the present prospective study, we enrolled lateralized PA patients who underwent adrenalectomy and were followed up 12 months after operation in the Taiwan Primary Aldosteronism Investigation (TAIPAI) registry from 2010 to 2018. The clinical outcome was kidney function impairment, defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 at 12 months after adrenalectomy. End organ damage is determined by microalbuminuria and left ventricular mass. Results: In total, 323 patients [mean, 50.8 ± 10.9 years old; female 178 (55.1%)] were enrolled. Comparing pre-operation and post-operation data, systolic blood pressure, serum aldosterone, urinary albumin to creatinine ratio and eGFR decreased. TTKG ? 4.9 correlated with pre-operative urinary albumin to creatinine ratio >50 mg/g [odds ratio (OR) = 2.42; p = 0.034] and left ventricular mass (B = 20.10; p = 0.018). Multivariate logistic regression analysis demonstrated that TTKG ? 4.9 could predict concealed chronic kidney disease (OR = 5.42; p = 0.011) and clinical success (OR = 2.90, p = 0.017) at 12 months after adrenalectomy. Conclusions: TTKG could predict concealed kidney function impairment and cure of hypertension in PA patients after adrenalectomy. TTKG more than 4.9 as an adverse surrogate of aldosterone and hypokalaemia correlated with pre-operative end organ damage in terms of high proteinuria and cardiac hypertrophy. ? The Author(s), 2020. | en_US |
dc.relation.ispartof | Therapeutic Advances in Chronic Disease | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 6beta iodomethyl 19 norcholest 5(10) en 3beta ol i 131; aldosterone; alpha adrenergic receptor blocking agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; captopril; creatinine; dipeptidyl carboxypeptidase inhibitor; diuretic agent; doxazosin; potassium; vasodilator agent; adrenalectomy; adult; albumin to creatinine ratio; Article; biological activity; cohort analysis; controlled study; diabetes mellitus; diastolic blood pressure; disease registry; echocardiography; endothelial dysfunction; estimated glomerular filtration rate; evaluation and follow up; female; heart left ventricle ejection fraction; heart left ventricle mass; human; hypertension; hypokalemia; intracardiac echocardiography; investigative procedures; kidney failure; kidney function test; logistic regression analysis; major clinical study; male; microalbuminuria; middle aged; osmolality; outcome assessment; plasma renin activity; primary aldosteronism surgery outcome; primary hyperaldosteronism; prospective study; radioimmunoassay; sensitivity analysis; single photon emission computed tomography-computed tomography; systolic blood pressure; taiwan primary aldosteronism investigation registry; transtubular potassium gradient; two dimensional echocardiography; ultrafiltration; urinalysis | - |
dc.title | Transtubular potassium gradient predicts kidney function impairment after adrenalectomy in primary aldosteronism | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1177/2040622320944792 | - |
dc.identifier.scopus | 2-s2.0-85089901666 | - |
dc.relation.journalvolume | 11 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUHHC | - |
crisitem.author.dept | Urology-NTUHBH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Medical Imaging-NTUCC | - |
crisitem.author.dept | Forensic Medicine | - |
crisitem.author.dept | Medical Imaging-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry-NTUHHC | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-2090-1757 | - |
crisitem.author.orcid | 0000-0003-4529-3161 | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.orcid | 0000-0002-0713-4904 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0002-0552-372X | - |
crisitem.author.orcid | 0000-0001-9170-2566 | - |
crisitem.author.orcid | 0000-0003-4100-8909 | - |
crisitem.author.orcid | 0000-0002-0121-4866 | - |
crisitem.author.orcid | 0000-0002-0989-0578 | - |
crisitem.author.orcid | 0000-0001-7505-6429 | - |
crisitem.author.orcid | 0000-0003-4129-0879 | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.orcid | 0000-0003-3114-582X | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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