https://scholars.lib.ntu.edu.tw/handle/123456789/514500
Title: | The Cost-utility Analysis of 18-Fluoro-2-Deoxyglucose Positron Emission Tomography in the Diagnosis of Recurrent Nasopharyngeal Carcinoma | Authors: | RUOH-FANG YEN Yen M.-F. RUEY-LONG HONG KAI-YUAN TZEN Chien C.-R. Chen, Tony Hsiu Hsi |
Issue Date: | 2009 | Journal Volume: | 16 | Journal Issue: | 1 | Start page/Pages: | 54-60 | Source: | Academic Radiology | Abstract: | Rationale and Objectives: 18-Fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET) is effective but costly in the early detection of recurrence for nasopharyngeal carcinoma (NPC) in patients after treatment. In this study, we developed a decision tree model to analyze the cost utility of 18F-FDG PET in detecting loco-regional recurrences for NPC patients after therapy. Materials and Methods: The analysis for cost utility is based on the decision-tree model for three different strategies: 1) magnetic resonance imaging (MRI)-only, 2) PET-only, and 3) MRI-PET (performing PET if MRI result is uncertain). Sensitivity analyses have been performed to examine changes in the cost ratio of PET/MRI and the probability of uncertain MRI. Results: After inputting the data for utilities and life expectancies into the decision tree model, the quality-adjusted life expectancies turn out to be 16.16 quality-adjusted life-years (QALYs) for strategy 1, 16.70 QALYs for strategy 2, and 17.35 QALYs for strategy 3. The additional cost per additional QALYs for strategy 3 relative to strategy 1 is calculated to be US $462. Strategy 3 dominates over strategy 2 because strategy 3 costs less and yields more QALYs than strategy 2. If the cost ratio of PET/MRI is less than 1.85 or the probability of uncertain MRI is greater than 73%, then the PET-only strategy becomes more cost-effective than the MRI-PET strategy. Conclusion: Our analysis shows that the MRI-PET strategy is the most cost-effective for now. It is likely the PET-only strategy will become the most cost-effective for recurrent NPC in patients in the near future as the cost of PET has decreased in a faster rate than the cost of MRI. ? 2009 AUR. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514500 | ISSN: | 1076-6332 | DOI: | 10.1016/j.acra.2008.06.012 | SDG/Keyword: | fluorodeoxyglucose f 18; adult; article; clinical article; controlled study; cost benefit analysis; cost utility analysis; decision tree; diagnostic accuracy; early diagnosis; female; human; life expectancy; male; nasopharynx carcinoma; nuclear magnetic resonance imaging; outcome assessment; positron emission tomography; priority journal; probability; quality adjusted life year; recurrent cancer; sensitivity analysis; visual analog scale; Adult; Cost-Benefit Analysis; Female; Fluorodeoxyglucose F18; Health Care Costs; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Positron-Emission Tomography; Radiopharmaceuticals; Taiwan |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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