|Title:||Abnormal regional cerebral blood flow found by technetium-99m ethyl cysteinate dimer brain single photon emission computed tomography in systemic lupus erythematosus patients with normal brain MRI findings||Authors:||Chen J.J.-H.
|Issue Date:||2002||Journal Volume:||21||Journal Issue:||6||Start page/Pages:||516-519||Source:||Clinical Rheumatology||Abstract:||
In this study, technetium-99m ethyl cysteinate dimer (99mTc ECD) brain single photon emission computed tomography (SPECT) was used to detect regional cerebral blood flow (rCBF) of the brain in SLE patients with normal brain magnetic resonance imaging (MRI) findings. Twenty female SLE patients were enrolled in this study, divided into two groups. Group 1 consisted of 10 patients with neuropsychiatric manifestations. Group 2 consisted of 10 patients without neuropsychiatric manifestations. All patients had normal brain MRI findings. Another 10 SLE patients with abnormal MRI findings were included as group 3 for comparison. Meanwhile, 10 healthy female volunteers also underwent brain MRI and 99mTc ECD brain SPECT for comparison. The scans revealed hypoperfusion lesions in 9/20 (45%) SLE patients, including 7/10 (70%) cases in group 1 and 2/10 (20%) cases in group 2. In contrast, all 10 patients (100%) in group 3 had abnormal 99mTc ECD brain SPECT findings. The parietal lobes were the most commonly involved areas. We conclude that 99mTc ECD brain SPECT is more sensitive for detecting rCBF changes than is brain MRI in detecting the brain anatomic changes, and may have a diagnostic value in lupus cerebral involvement. However, 99mTc ECD brain SPECT may not be indicated for SLE patients with normal MRI and mild neuropsychiatric symptoms/signs, such headaches and dizziness.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/514553||ISSN:||0770-3198||DOI:||10.1007/s100670200126||SDG/Keyword:||cysteine ethyl ester tc 99m; adult; article; brain blood flow; brain disease; brain injury; brain perfusion; clinical article; clinical feature; controlled study; diagnostic value; female; headache; human; intermethod comparison; mental disease; neurologic disease; nuclear magnetic resonance imaging; parietal lobe; pathological anatomy; priority journal; sensitivity analysis; single photon emission computer tomography; systemic lupus erythematosus; vertigo; Adult; Cerebrovascular Circulation; Cysteine; Female; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Organotechnetium Compounds; Prospective Studies; Regional Blood Flow; Sensitivity and Specificity; Telencephalon; Tomography, Emission-Computed, Single-Photon
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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