https://scholars.lib.ntu.edu.tw/handle/123456789/514554
標題: | Comparing whole body 18F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphate bone scan to detect bone metastases in patients with renal cell carcinomas - A preliminary report | 作者: | Wu H. RUOH-FANG YEN Shen Y. Kao C. Lin C. Lee C. |
公開日期: | 2002 | 卷: | 128 | 期: | 9 | 起(迄)頁: | 503-506 | 來源出版物: | Journal of Cancer Research and Clinical Oncology | 摘要: | Purpose: Conventional technetium-99m methylene diphosphate whole body bone scan (bone scan) has a high sensitivity but a poor specificity to detect bone metastases. However, positron emission tomography with 18F-2-deoxyglucose (FDG-PET) can offer superior spatial resolution and improved specificity. We have attempted to evaluate the usefulness of FDG-PET for detecting bone metastases in renal cell carcinomas (RCC) and to compare FDG-PET results with bone scan findings. Methods: Eighteen patients were selected for this study with biopsy-proven RCC. They were suspected of having bone metastases and were undergoing bone scan and FDG-PET to detect bone metastases. The final diagnoses of bone metastases were established by operative, histopathological findings or clinical follow-up longer than 1 year by additional radiographs or following FDG-PET/bone scan findings showing progressive and extensive widespread bone lesions. Results: A total of 52 bone lesions including 40 metastatic and 12 benign bone lesions found on either FDG-PET or bone scan were evaluated. FDG-PET could accurately diagnose all 40 metastatic and 12 benign bone lesions. Bone scan could accurately diagnose only 31 metastatic bone lesions. Diagnostic sensitivity and accuracy of FDG-PET were 100% and 100%, respectively, and bone scan were 77.5% and 59.6%, respectively. Conclusions: Our data suggest that FDG-PET has a higher sensitivity and a better accuracy than that of bone scan to detect bone metastases in patients with RCC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514554 | ISSN: | 0171-5216 | DOI: | 10.1007/s00432-002-0370-1 | SDG/關鍵字: | fluorodeoxyglucose f 18; medronate technetium tc 99m; adult; aged; article; bone lesion; bone metastasis; bone scintiscanning; cancer diagnosis; cancer scintiscanning; clinical article; controlled study; diagnostic accuracy; evaluation; female; follow up; histopathology; human; human tissue; intermethod comparison; kidney carcinoma; male; positron emission tomography; priority journal; radiodiagnosis; radiography; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Female; Fluorodeoxyglucose F18; Humans; Kidney Neoplasms; Male; Middle Aged; Technetium Tc 99m Medronate; Tomography, Emission-Computed |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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