https://scholars.lib.ntu.edu.tw/handle/123456789/514578
標題: | The role of FDG-PET, HMPAO-SPET and MRI in the detection of brain involvement in patients with systemic lupus erythematosus | 作者: | Kao C.-H. Lan J.-L. ChangLai S.-P. Liao K.-K. RUOH-FANG YEN Chieng P.-U. |
公開日期: | 1999 | 卷: | 26 | 期: | 2 | 起(迄)頁: | 129-134 | 來源出版物: | European Journal of Nuclear Medicine | 摘要: | Involvement of the brain is one of the most important complications of systemic lupus erythematosus (SLE); however, its diagnosis is difficult due to the lack of effective imaging methods. We combined three brain imaging modalities - positron emission tomography with fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG-PET), single-photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime (HMPAO-SPET) and magnetic resonance imaging (MRI) - in order to detect brain involvement in SLE. Thirty-seven SLE patients, aged 22-45 years, were divided into three groups. Group 1 (G1) consisted of ten patients with major neuropsychiatric manifestations; group 2 (G2) consisted of 15 patients with minor manifestations; and group 3 (G3) consisted of 12 patients without manifestations. FDG-PET findings were abnormal in 51% of patients: 90% of G1, 67% of G2 and 0% of G3 patients respectively. HMPAO-SPET findings were abnormal in 62% of patients: 100% of G1, 73% of G2 and 17% of G3 patients respectively. MRI findings were abnormal in 35% of patients: 70% of G1, 40% of G2 and 0% of G3 patients respectively. Grey matter was more commonly involved than white matter; 62% of patients presented with lesions in the cerebral cortex, 27% with lesions in the basal ganglion, 5% with lesions in the cerebellum, and 19% with lesions in white matter. No white matter lesions were found on FDG-PET or HMPAO-SPET. However, in 19% of patients, MRI demonstrated abnormally high signal lesions in white matter. Forty-three percent of cases had positive serum anticardiolipin antibodies (ACA). However, ACA was not related to FDG-PET, HMPAO-SPET or MRI findings. It may be concluding that HMPAO-SPET is a more sensitive tool for detecting brain involvement in SLE patients when compared with FDG-PET or MRI. However, MRI is necessary for detecting lesions in white matter. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514578 | ISSN: | 0340-6997 | DOI: | 10.1007/s002590050368 | SDG/關鍵字: | cardiolipin antibody; fluorodeoxyglucose f 18; hexamethylpropylene amine oxime technetium tc 99m; adult; antibody blood level; article; basal ganglion; brain cortex; brain disease; clinical article; female; gray matter; human; human cell; neuropsychiatry; nuclear magnetic resonance imaging; positron emission tomography; radioimmunoassay; scintillation camera; single photon emission computer tomography; systemic lupus erythematosus; white matter; Adult; Antibodies, Anticardiolipin; Brain; Female; Fluorodeoxyglucose F18; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Middle Aged; Radiopharmaceuticals; Sensitivity and Specificity; Technetium Tc 99m Exametazime; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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