https://scholars.lib.ntu.edu.tw/handle/123456789/514578
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kao C.-H. | en_US |
dc.contributor.author | Lan J.-L. | en_US |
dc.contributor.author | ChangLai S.-P. | en_US |
dc.contributor.author | Liao K.-K. | en_US |
dc.contributor.author | RUOH-FANG YEN | en_US |
dc.contributor.author | Chieng P.-U. | en_US |
dc.creator | Kao C.-H.;Lan J.-L.;Changlai S.-P.;Liao K.-K.;Ruoh-Fang Yen;Chieng P.-U. | - |
dc.date.accessioned | 2020-09-23T06:22:53Z | - |
dc.date.available | 2020-09-23T06:22:53Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0340-6997 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514578 | - |
dc.description.abstract | Involvement of the brain is one of the most important complications of systemic lupus erythematosus (SLE); however, its diagnosis is difficult due to the lack of effective imaging methods. We combined three brain imaging modalities - positron emission tomography with fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG-PET), single-photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime (HMPAO-SPET) and magnetic resonance imaging (MRI) - in order to detect brain involvement in SLE. Thirty-seven SLE patients, aged 22-45 years, were divided into three groups. Group 1 (G1) consisted of ten patients with major neuropsychiatric manifestations; group 2 (G2) consisted of 15 patients with minor manifestations; and group 3 (G3) consisted of 12 patients without manifestations. FDG-PET findings were abnormal in 51% of patients: 90% of G1, 67% of G2 and 0% of G3 patients respectively. HMPAO-SPET findings were abnormal in 62% of patients: 100% of G1, 73% of G2 and 17% of G3 patients respectively. MRI findings were abnormal in 35% of patients: 70% of G1, 40% of G2 and 0% of G3 patients respectively. Grey matter was more commonly involved than white matter; 62% of patients presented with lesions in the cerebral cortex, 27% with lesions in the basal ganglion, 5% with lesions in the cerebellum, and 19% with lesions in white matter. No white matter lesions were found on FDG-PET or HMPAO-SPET. However, in 19% of patients, MRI demonstrated abnormally high signal lesions in white matter. Forty-three percent of cases had positive serum anticardiolipin antibodies (ACA). However, ACA was not related to FDG-PET, HMPAO-SPET or MRI findings. It may be concluding that HMPAO-SPET is a more sensitive tool for detecting brain involvement in SLE patients when compared with FDG-PET or MRI. However, MRI is necessary for detecting lesions in white matter. | - |
dc.relation.ispartof | European Journal of Nuclear Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cardiolipin antibody; fluorodeoxyglucose f 18; hexamethylpropylene amine oxime technetium tc 99m; adult; antibody blood level; article; basal ganglion; brain cortex; brain disease; clinical article; female; gray matter; human; human cell; neuropsychiatry; nuclear magnetic resonance imaging; positron emission tomography; radioimmunoassay; scintillation camera; single photon emission computer tomography; systemic lupus erythematosus; white matter; Adult; Antibodies, Anticardiolipin; Brain; Female; Fluorodeoxyglucose F18; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Middle Aged; Radiopharmaceuticals; Sensitivity and Specificity; Technetium Tc 99m Exametazime; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | - |
dc.title | The role of FDG-PET, HMPAO-SPET and MRI in the detection of brain involvement in patients with systemic lupus erythematosus | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s002590050368 | - |
dc.identifier.pmid | 9933346 | - |
dc.identifier.scopus | 2-s2.0-0033029751 | - |
dc.relation.pages | 129-134 | - |
dc.relation.journalvolume | 26 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1648-6482 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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