https://scholars.lib.ntu.edu.tw/handle/123456789/514727
Title: | The association between urinary levels of 1,3-butadiene metabolites, cardiovascular risk factors, microparticles, and oxidative stress products in adolescents and young adults | Authors: | Lin C.-Y. Lee H.-L. Jung W.-T. Sung F.-C. TA-CHEN SU |
Keywords: | 1,3-Butadiene (BD); 8-Hydroxydeoxyguanosine (8-OHdG); Endothelial microparticles (EMPs); N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA); Platelet microparticles (PMPs) | Issue Date: | 2020 | Publisher: | Elsevier B.V. | Journal Volume: | 396 | Start page/Pages: | 122745 | Source: | Journal of Hazardous Materials | Abstract: | 1,3-Butadiene (BD) is a synthetic colorless gas used in the production of synthetic rubber and polymers. Exposure to BD has been reported to increase oxidative stress and accelerate atherosclerosis in vitro and in animal studies. In occupational studies, BD exposure has been linked to cardiovascular disease (CVD). However, no previous research has been reported on whether BD exposure is associated with CVD risk factors and oxidative stress in the general population. We recruited 853 young participants to study the correlation between urinary levels of the BD metabolite, N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA), CVD risk factors, serum levels of endothelial microparticles and platelet microparticles, and the urinary levels of 8-hydroxydeoxyguanosine (8-OHdG). The results showed the DHBMA levels were positively correlated with low-density lipoprotein-C, carotid intima-media thickness (CIMT), CD31+/CD42a ? counts (endothelial apoptosis markers), and urinary 8-OHdG levels. Moreover, DHBMA levels were negatively correlated with CD62 P counts (platelet activation marker). The correlation between DHBMA, CIMT, and 8-OHdG was more evident when the levels of CD31+/CD42a ? or CD62 P were above 50%. In conclusion, we reported that the urinary levels of DHBMA were associated with the lipid profile, CIMT, microparticles, and marker of oxidative stress in this young population. Future studies on BD exposure and atherosclerosis are needed. ? 2020 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083738330&doi=10.1016%2fj.jhazmat.2020.122745&partnerID=40&md5=647036e362bc75e721f9089d4f83a84a https://scholars.lib.ntu.edu.tw/handle/123456789/514727 |
ISSN: | 0304-3894 | DOI: | 10.1016/j.jhazmat.2020.122745 | SDG/Keyword: | Amino acids; Cell death; Diseases; Gas industry; Oxidative stress; Platelets; Rubber industry; Synthetic rubber; 1 ,3-butadiene; Cardio-vascular risk factors; Cardiovascular disease; Carotid intima-media thickness; General population; Low density lipoproteins; Micro-particles; Platelet activation; Metabolites; 1,3 butadiene derivative; 8 hydroxydeoxyguanosine; biological marker; cd42a antigen; low density lipoprotein cholesterol; lymphocyte antigen; n acetyl s (3,4 dihydroxybutyl) levo cysteine; PADGEM protein; platelet endothelial cell adhesion molecule 1; toxic substance; unclassified drug; 1,3 butadiene; 1,3-butadiene; biological marker; apoptosis; cardiovascular disease; chemical compound; disease; metabolite; oxidative stress; risk factor; serum; urine; young population; adolescent; adult; apoptosis; arterial wall thickness; Article; cardiovascular disease; cardiovascular risk; child; cohort analysis; correlation coefficient; cross-sectional study; disease association; endothelial dysfunction; endothelial microparticle; female; human; lipid fingerprinting; major clinical study; male; oxidative stress; platelet microparticle; thrombocyte activation; urine level; vascular endothelium; young adult; animal; cardiovascular disease; oxidative stress; risk factor; Animalia; Adolescent; Animals; Biomarkers; Butadienes; Cardiovascular Diseases; Carotid Intima-Media Thickness; Heart Disease Risk Factors; Humans; Oxidative Stress; Risk Factors; Young Adult |
Appears in Collections: | 醫學系 |
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