https://scholars.lib.ntu.edu.tw/handle/123456789/514731
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang W.-S. | en_US |
dc.contributor.author | Chen Y.-Y. | en_US |
dc.contributor.author | Chen P.-C. | en_US |
dc.contributor.author | Hsu H.-C. | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.contributor.author | HUNG-JU LIN | en_US |
dc.contributor.author | MING-FONG CHEN | en_US |
dc.contributor.author | Lee Y.-T. | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.creator | Yang W.-S.;Chen Y.-Y.;Chen P.-C.;Hsu H.-C.;Ta-Chen Su;Lin H.-J.;Chen M.-F.;Lee Y.-T.;Chien K.-L. | - |
dc.date.accessioned | 2020-09-28T02:47:21Z | - |
dc.date.available | 2020-09-28T02:47:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076552395&doi=10.1038%2fs41598-019-55686-7&partnerID=40&md5=42874d5131adcae1683407efbb34918c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514731 | - |
dc.description.abstract | Most studies support that saturated fatty acid replacement with polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular diseases (CVDs) and put emphasis on the effects of N-3 PUFAs. The reported relationships between N-6 PUFAs and CVD risks vary. We aimed to examine the associations between N-6 PUFA concentrations and CVD risks. In this community-based prospective cohort study on CVD-free patients at baseline (N = 1835, age: 60.6 ± 10.5 years, women: 44.5%), we measured the fatty acid concentrations in the blood using gas chromatography. Four hundred twenty-four participants developed CVDs during follow up. The total N-6 PUFA concentration was inversely associated with the CVD risk, with a 48% lower risk in the highest N-6 PUFA concentration quartile (hazard ratio = 0.52; P for trend <0.001). The estimated population attributable risk of N-6 PUFAs indicated that approximately 20.7% of CVD events would have been prevented if the plasma N-6 PUFA concentration had been higher than the median value. The total N-6 PUFA concentration presented the highest net reclassification improvement (NRI = 7.2%, P = 0.03) for predicting incident CVD. Further studies on N-6 PUFAs, diet habits, and their relationships with healthcare are warranted. ? 2019, The Author(s). | - |
dc.publisher | Nature Research | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | omega 6 fatty acid; unsaturated fatty acid; aged; blood; cardiovascular disease; fat intake; feeding behavior; female; follow up; gas chromatography; genetic predisposition; health care delivery; human; male; middle aged; pathology; risk factor; Aged; Cardiovascular Diseases; Chromatography, Gas; Delivery of Health Care; Dietary Fats; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Feeding Behavior; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Risk Factors | - |
dc.title | Association between Plasma N-6 Polyunsaturated Fatty Acids Levels and the Risk of Cardiovascular Disease in a Community-based Cohort Study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-019-55686-7 | - |
dc.identifier.pmid | 31848413 | - |
dc.identifier.scopus | 2-s2.0-85076552395 | - |
dc.relation.pages | 19298 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHBH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.orcid | 0000-0003-1046-2308 | - |
crisitem.author.orcid | 0000-0001-6633-7632 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
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