https://scholars.lib.ntu.edu.tw/handle/123456789/514738
標題: | Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults | 作者: | Lin C.-Y. Hwang Y.-T. PAU-CHUNG CHEN Sung F.-C. TA-CHEN SU |
公開日期: | 2019 | 出版社: | Elsevier Ltd | 卷: | 246 | 起(迄)頁: | 107-113 | 來源出版物: | Environmental Pollution | 摘要: | 4-tertiary-Octylphenol levels were correlated with CVD risk factors and subclinical atherosclerosis in this cohort of adolescents and young adults. ? 2018 Elsevier LtdIn the family of alkylphenolic compounds, 4-tertiary-Octylphenol (4-t-OP) is extensively used in many products. In animal and in vitro studies, 4-t-OP exposure has been linked to cardiovascular disease (CVD) risk factors; however, there are no previous human epidemiological studies. In this study, 886 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between serum levels of 4-t-OP, CVD risk factors, and common carotid artery intima-media thickness (CIMT). The geometric mean (SD) 4-t-OP concentration was 32.52 (1.71) ng/mL. We found that serum levels of 4-t-OP were negatively associated with markers of glucose homeostasis (insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β)), z score of body mass index (BMI z score) and CIMT but were positively associated with lipid profiles (high density lipoprotein cholesterol (HDL-C), Apolipoprotein A1). A one-unit elevation in natural log-transformed 4-t-OP (ng/mL) was negatively correlated with CIMT (mm) (β = ?0.029, SE = 0.003, P < 0.001) in multiple linear regression analyses. The relationship between 4-t-OP and CIMT remained the same in all subgroups or if bisphenol A (BPA) was considered a covariate. In this study, we observed that higher levels of 4-t-OP levels were negatively correlated with markers of glucose homeostasis, BMI z score, and CIMT; positively correlated with lipid profiles (HDL-C and apolipoprotein A) in this cohort. Future research on exposure to 4-t-OP and CVD risk factors is warranted. ? 2018 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059322589&doi=10.1016%2fj.envpol.2018.11.110&partnerID=40&md5=74f07848c97cc281d09586e8f6cde69e https://scholars.lib.ntu.edu.tw/handle/123456789/514738 |
ISSN: | 0269-7491 | DOI: | 10.1016/j.envpol.2018.11.110 | SDG/關鍵字: | Cardiology; Diseases; Glucose; Insulin; Linear regression; Lipoproteins; Phenols; 4-Tertiary-Octylphenol (4-t-OP); Bisphenol A; Cardio-vascular disease risk factors; Insulin resistance; Intima-media thickness; Risk assessment; 4 tert octylphenol; 4,4' isopropylidenediphenol; apolipoprotein A1; glucose; high density lipoprotein cholesterol; insulin; lipid; 4-tert-octylphenol; phenol derivative; adolescence; assessment method; cardiovascular disease; homeostasis; phenol; risk factor; serum; young population; adolescent; adult; arterial wall thickness; Article; blood level; body mass; cardiovascular risk; child; cohort analysis; concentration (parameter); controlled study; cross-sectional study; female; glucose homeostasis; homeostasis model assessment; human; male; pancreas islet beta cell; pancreas islet cell function; Taiwanese; blood; cardiovascular disease; pathophysiology; risk factor; Taiwan; young adult; Taiwan; Adolescent; Adult; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cohort Studies; Female; Humans; Male; Phenols; Risk Factors; Taiwan; Young Adult |
顯示於: | 醫學系 |
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