https://scholars.lib.ntu.edu.tw/handle/123456789/514738
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Hwang Y.-T. | en_US |
dc.contributor.author | PAU-CHUNG CHEN | en_US |
dc.contributor.author | Sung F.-C. | en_US |
dc.contributor.author | TA-CHEN SU | en_US |
dc.creator | Lin C.-Y.;Hwang Y.-T.;Chen P.-C.;Sung F.-C.;Ta-Chen Su | - |
dc.date.accessioned | 2020-09-28T02:47:23Z | - |
dc.date.available | 2020-09-28T02:47:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0269-7491 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059322589&doi=10.1016%2fj.envpol.2018.11.110&partnerID=40&md5=74f07848c97cc281d09586e8f6cde69e | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/514738 | - |
dc.description.abstract | 4-tertiary-Octylphenol levels were correlated with CVD risk factors and subclinical atherosclerosis in this cohort of adolescents and young adults. ? 2018 Elsevier LtdIn the family of alkylphenolic compounds, 4-tertiary-Octylphenol (4-t-OP) is extensively used in many products. In animal and in vitro studies, 4-t-OP exposure has been linked to cardiovascular disease (CVD) risk factors; however, there are no previous human epidemiological studies. In this study, 886 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between serum levels of 4-t-OP, CVD risk factors, and common carotid artery intima-media thickness (CIMT). The geometric mean (SD) 4-t-OP concentration was 32.52 (1.71) ng/mL. We found that serum levels of 4-t-OP were negatively associated with markers of glucose homeostasis (insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β)), z score of body mass index (BMI z score) and CIMT but were positively associated with lipid profiles (high density lipoprotein cholesterol (HDL-C), Apolipoprotein A1). A one-unit elevation in natural log-transformed 4-t-OP (ng/mL) was negatively correlated with CIMT (mm) (β = ?0.029, SE = 0.003, P < 0.001) in multiple linear regression analyses. The relationship between 4-t-OP and CIMT remained the same in all subgroups or if bisphenol A (BPA) was considered a covariate. In this study, we observed that higher levels of 4-t-OP levels were negatively correlated with markers of glucose homeostasis, BMI z score, and CIMT; positively correlated with lipid profiles (HDL-C and apolipoprotein A) in this cohort. Future research on exposure to 4-t-OP and CVD risk factors is warranted. ? 2018 Elsevier Ltd | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Environmental Pollution | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Cardiology; Diseases; Glucose; Insulin; Linear regression; Lipoproteins; Phenols; 4-Tertiary-Octylphenol (4-t-OP); Bisphenol A; Cardio-vascular disease risk factors; Insulin resistance; Intima-media thickness; Risk assessment; 4 tert octylphenol; 4,4' isopropylidenediphenol; apolipoprotein A1; glucose; high density lipoprotein cholesterol; insulin; lipid; 4-tert-octylphenol; phenol derivative; adolescence; assessment method; cardiovascular disease; homeostasis; phenol; risk factor; serum; young population; adolescent; adult; arterial wall thickness; Article; blood level; body mass; cardiovascular risk; child; cohort analysis; concentration (parameter); controlled study; cross-sectional study; female; glucose homeostasis; homeostasis model assessment; human; male; pancreas islet beta cell; pancreas islet cell function; Taiwanese; blood; cardiovascular disease; pathophysiology; risk factor; Taiwan; young adult; Taiwan; Adolescent; Adult; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cohort Studies; Female; Humans; Male; Phenols; Risk Factors; Taiwan; Young Adult | - |
dc.title | Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.envpol.2018.11.110 | - |
dc.identifier.pmid | 30529934 | - |
dc.identifier.scopus | 2-s2.0-85059322589 | - |
dc.relation.pages | 107-113 | - |
dc.relation.journalvolume | 246 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.dept | Environmental and Occupational Medicine | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-6242-5974 | - |
crisitem.author.orcid | 0000-0001-7523-7166 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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