https://scholars.lib.ntu.edu.tw/handle/123456789/514771
標題: | Serum perfluorinated chemicals, glucose homeostasis and the risk of diabetes in working-aged Taiwanese adults | 作者: | TA-CHEN SU Kuo, Chin-Chi HWANG, JUEY-JEN Lien, Guang-Wen MING-FONG CHEN PAU-CHUNG CHEN |
公開日期: | 1-三月-2016 | 出版社: | Elsevier Ltd | 卷: | 88 | 起(迄)頁: | 15-22 | 來源出版物: | Environment International | 摘要: | Background: The link among perfluoroalkyl and polyfluoroalkyl substances (PFASs), abnormal glucose homeostasis and the risk of diabetes has been intensively debated with conflicting evidence. Objectives: We evaluated the associations among PFASs, oral glucose tolerance testing (OGTT) curves and diabetes prevalence in 571 working-aged Taiwanese participants. Methods: Exposure measures included serum perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA). Outcomes were OGTT curves and prevalent diabetes defined by fasting blood glucose (FBG) ?. 126. mg/dL, 2-h glucose ?. 200. mg/dL, or glycated hemoglobin ?. 6.5%. Analyses were performed with multiple logistic regression and functional data analysis. Results: A total of 39 participants (6.8%) had diabetes in this study. After full adjustment, the increase in the geometric means of FBG, 2-h glucose concentrations, and area under the OGTT curve (AUC120) with a doubling increase in PFOS was 3% (95% CI 1-4), 8% (5-12), and 6% (4-9), respectively. Compared to the lowest-quartile of PFOS concentrations (<2.4ng/ml), the OGTT trajectories were significantly steeper in participants of the highest-quartile PFOS exposure (>4.8ng/ml) and the vertical shifting of the mean curve for each PFOS quartile showed a dose-response pattern. The adjusted odds ratio for diabetes comparing the highest to lowest quartile was 3.37 (95% CI 1.18-9.65). For PFOA, PFNA, and PFUA, the opposite pattern of OGTT trajectory and the opposite risk profile for diabetes were observed. Conclusions: Chronic PFOS exposure was associated with impaired glucose homeostasis and the increased prevalence of diabetes. However, PFOA, PFNA, and PFUA showed a potential protective effect against glucose intolerance and the risk of diabetes. Future research focusing on clarifying possible differential effects of different species of PFASs on glucose homeostasis and establishing the prospective associations between PFASs and diabetes is needed. ? 2015 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949651823&doi=10.1016%2fj.envint.2015.11.016&partnerID=40&md5=b5651c6f811cee57b900691f009a641f https://scholars.lib.ntu.edu.tw/handle/123456789/514771 |
ISSN: | 0160-4120 | DOI: | 10.1016/j.envint.2015.11.016 | SDG/關鍵字: | Logistic regression; Medical problems; Functional data analysis; Glucose homeostasis; Glucose tolerance; Multiple logistic regression; Perfluorinated chemicals; Perfluorononanoic acids; Perfluorooctane sulfonic acids; Polyfluoroalkyl substances; Glucose; glucose; hemoglobin A1c; perfluorononanoic acid; perfluorooctanesulfonic acid; perfluorooctanoic acid; perfluoroundecanoic acid; fluorocarbon; pollutant; adult; diabetes; disease prevalence; glucose; homeostasis; risk factor; serum; tolerance; adult; aged; Article; diabetes mellitus; diet restriction; female; glucose blood level; glucose homeostasis; glucose intolerance; human; long term exposure; major clinical study; male; occupational exposure; oral glucose tolerance test; prevalence; priority journal; risk assessment; risk factor; Taiwanese; worker; blood; diabetes mellitus; homeostasis; metabolism; middle aged; multivariate analysis; odds ratio; physiology; pollutant; prospective study; risk factor; statistical model; Taiwan; toxicity; Taiwan; Adult; Diabetes Mellitus; Environmental Pollutants; Female; Fluorocarbons; Glucose; Homeostasis; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Prevalence; Prospective Studies; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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