https://scholars.lib.ntu.edu.tw/handle/123456789/514797
標題: | Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults | 作者: | Lin C.-Y. Lee H.-L. Chen Y.-C. Lien G.-W. LIAN-YU LIN Wen L.-L. Liao C.-C. KUO-LIONG CHIEN Sung F.-C. PAU-CHUNG CHEN TA-CHEN SU |
公開日期: | 2013 | 卷: | 261 | 起(迄)頁: | 372-377 | 來源出版物: | Journal of Hazardous Materials | 摘要: | Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if urinary levels of the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine (AAMA) and the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) are associated. The mean (SD) AAMA and 8-OHdG were 76.54 (76.42). μg/L and 3.48 (2.37). μg/L, respectively. In linear regression analyses, a 1-unit increase in natural log AAMA was significantly associated with an increase in natural log 8-OHdG (μg/g creatinine) (β=0.044, SE=0.019, P=0.020) after controlling for covariates. Subpopulation analyses showed AAMA and 8-OHdG were significantly associated with males, adolescents, non-current smokers, without alcohol consumption, subjects, body mass index ?24, and homeostasis model assessment of insulin resistance score ?0.9. In conclusion, higher urinary AAMA concentrations were associated with increased levels of urinary 8-OHdG in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and oxidative stress. ? 2013 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84882760234&doi=10.1016%2fj.jhazmat.2013.06.069&partnerID=40&md5=28cfd619dbecd9222e6f3761c32367fc https://scholars.lib.ntu.edu.tw/handle/123456789/514797 |
ISSN: | 0304-3894 | DOI: | 10.1016/j.jhazmat.2013.06.069 | SDG/關鍵字: | 8-Hydroxydeoxyguanosine (8-OHdG); Acrylamides; Alcohol consumption; Causal relationships; Homeostasis model assessments; Insulin resistance; Mainstream cigarette smoke; N-Acetyl-S-(propionamide)-cysteine (AAMA); Amides; Amino acids; Metabolites; Oxidative stress; Regression analysis; Chemical contamination; 8 hydroxydeoxyguanosine; acrylamide; creatinine; cysteine derivative; n acetyl s (propionamide) cysteine; unclassified drug; adolescence; adult; bioaccumulation; body mass; concentration (composition); metabolite; oxidation; pollution exposure; polymer; public health; subpopulation; urine; adolescent; adult; alcohol consumption; article; body mass; cardiovascular risk; child; creatinine urine level; cross-sectional study; environmental exposure; female; homeostasis; human; insulin resistance; major clinical study; male; oxidative stress; population research; school child; smoking; Taiwan; urine level; Taiwan; 8-hydroxydeoxyguanosine; 8-Hydroxydeoxyguanosine (8-OHdG); 8-OHdG; AAMA; Acrylamide; BMI; body mass index; HDL-C; high-density lipoprotein cholesterol; HOMA-IR; LDL-C; limit of detection; LOD; low lipoprotein cholesterol; N-acetyl-S-(2-carbamoylethyl)-cysteine; N-Acetyl-S-(propionamide)-cysteine (AAMA); National Taiwan University Hospital; New Taiwan Dollars; NTD; NTUH; Oxidative stress; reactive oxygen species; ROS; The homeostasis model assessment of insulin resistance; Acetylcysteine; Acrylamide; Adolescent; Adult; Child; Deoxyguanosine; Environmental Monitoring; Female; Humans; Male; Taiwan; Young Adult |
顯示於: | 醫學系 |
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