|Title:||Association between sequence variant of c.553 G > T in the apolipoprotein A5 gene and metabolic syndrome, insulin resistance, and carotid atherosclerosis||Authors:||KUO-LIONG CHIEN
|Keywords:||[SDGs]SDG3||Issue Date:||2009||Publisher:||Mosby Inc.||Journal Volume:||154||Journal Issue:||3||Start page/Pages:||133-141||Source:||Translational Research||Abstract:||
Common polymorphism of the apolipoprotein A5 gene (APOA5, c.553 G > T) related to metabolic syndrome components, insulin resistance, and carotid atherosclerosis remains unclear. We investigated the associations of the APOA5 c.553 G > T gene with various metabolic syndrome components and carotid artery atherosclerosis among family members. A total of 661 participants who provided complete genotyping and carotid artery measures were included in this study. Participants with APOA5 c.553 T carrier (GT and TT) were more likely to have higher levels of triglycerides and apolipoprotein B, as well as lower levels of high-density lipoprotein (HDL) cholesterol, than participants with the GG genotype. Individuals who carried T alleles had an increased risk of a high level of triglycerides (multivariate odds ratio [OR], 3.86; 95% confidence interval [CI], 1.98-7.55; P < 0.0001) and low levels of HDL cholesterol (OR, 2.32; 95% CI, 1.40-3.86; P = 0.0012) compared with those without T?alleles. The age was an effect modifier for the association between APOA5 genotype and smoking, alcohol drinking, obesity, and lipid profiles, including total, HDL, and low-density lipoprotein (LDL) cholesterol; triglycerides; and apolipoproteins. In addition, the association between APOA5 genotype and hypertriglyceridemia was significant only in adult groups (OR, 3.53; 95% CI, 1.79-6.94), and the association between APOA5 genotype and low HDL cholesterol was stable in young adolescents (OR, 2.39; 95% CI, 1.19-4.78) and adults (OR, 2.20; 95% CI, 1.17-4.15). Our findings indicated that the APOA5 c.553 G > T polymorphism is associated with high triglycerides and low HDL cholesterol but not with other metabolic syndrome components or carotid atherosclerosis in this ethnic Chinese population. ? 2009.
|ISSN:||1931-5244||DOI:||10.1016/j.trsl.2009.06.005||SDG/Keyword:||apolipoprotein A5; apolipoprotein B; high density lipoprotein cholesterol; triacylglycerol; adult; allele; article; atherosclerosis; carotid artery; female; gene sequence; genetic association; genotype; human; insulin resistance; major clinical study; male; metabolic syndrome X; priority journal; risk factor
|Appears in Collections:||醫學系|
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