https://scholars.lib.ntu.edu.tw/handle/123456789/514910
標題: | Consistency of genetic inheritance mode and heritability patterns of triglyceride vs. high density lipoprotein cholesterol ratio in two Taiwanese family samples | 作者: | KUO-LIONG CHIEN Hsu H.-C. TA-CHEN SU Yang C.-Y. Lee Y.-T. |
公開日期: | 2003 | 卷: | 4 | 起(迄)頁: | 7 | 來源出版物: | BMC Genetics | 摘要: | Background: Triglyceride/HDL cholesterol ratio (TG/HDL-C) is considered as a risk factor for cardiovascular events. Genetic components were important in controlling the variation in western countries. But the mode of inheritance and family aggregation patterns were still unknown among Asian-Pacific countries. This study, based on families recruited from community and hospital, is aimed to investigate the mode of inheritance, heritability and shared environmental factors in controlling TG/HDL-C. Results: Two populations, one from community-based families (n = 988, 894 parent-offspring and 453 sibling pairs) and the other from hospital-based families (n = 1313, 76 parent-offspring and 52 sibling pairs) were sampled. The population in hospital-based families had higher mean age values than community-based families (54.7 vs. 34.0). Logarithmic transformed TG/ HDL-C values, after adjusted by age, gender and body mass index, were for genetic analyses. Significant parent-offspring and sibling correlations were also found in both samples. The parent-offspring correlation coefficient was higher in the hospital-based families than in the community-based families. Genetic heritability was higher in community-based families (0.338 ± 0.114, p = 0.002), but the common shared environmental factor was higher in hospital-based families (0.203 ± 0.042, p < 0.001). Commingling analyses showed that more than one-component distribution models were the bestfit models to explain the variance in both populations. Complex segregation analysis by regressive models revealed that in both samples the best-fit model of TG/HDL-C was the model of environmental effects plus familial correlation, in which significant parent-offspring and sibling correlations were demonstrated. Models of major gene effects were rejected in both samples. Conclusion: Variations of TG/HDL-C in the normal ranges were likely to be influenced by multiple factors, including environmental and genetic components. Higher genetic factors were proved in younger community-based families than in older hospital-based families. ? 2003 Chien et a; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-2442640299&doi=10.1186%2f1471-2156-4-7&partnerID=40&md5=923a85c52dd93a30df0d87afa1894d1b https://scholars.lib.ntu.edu.tw/handle/123456789/514910 |
ISSN: | 1471-2156 | DOI: | 10.1186/1471-2156-4-7 | SDG/關鍵字: | high density lipoprotein cholesterol; triacylglycerol; adult; age; analysis of variance; article; body mass; child parent relation; cholesterol blood level; community; controlled study; correlation coefficient; environmental factor; family; female; gender; gene segregation; genetic analysis; genetic model; heredity; hospital patient; human; linear regression analysis; male; multifactorial inheritance; population genetics; segregation analysis; sibling; statistical distribution; statistical significance; Taiwan; triacylglycerol blood level; Adult; Age Factors; Body Mass Index; Cholesterol, HDL; Community Health Centers; Female; Genes, Dominant; Genetic Variation; Genetics, Population; Hospitalization; Humans; Inheritance Patterns; Male; Middle Aged; Nuclear Family; Sex Factors; Siblings; Taiwan; Triglycerides |
顯示於: | 醫學系 |
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