https://scholars.lib.ntu.edu.tw/handle/123456789/514921
標題: | A randomized crossover evaluation of antianginal efficacy and safety of nitrolingual-spray and nitroglycerin tablet form in coronary artery disease patients | 作者: | KUO-LIONG CHIEN Sung F.-C. CHIA-LUN CHAO TA-CHEN SU MING-FONG CHEN Lee Y.-T. |
關鍵字: | Clinical trial; Coronary artery disease; Nitroglycerin; Treadmill exercise test | 公開日期: | 2000 | 出版社: | S. Karger AG | 卷: | 93 | 期: | 3 | 起(迄)頁: | 137-141 | 來源出版物: | Cardiology | 摘要: | Twenty-eight coronary artery disease patients with more than 50% stenosis in at least one major coronary artery completed this randomized crossover clinical trial for the comparison of efficacy and safety of Nitrolingual-Spray and nitroglycerin (NTG) tablets. Exercise time was lengthened to 399.1 s (spray) or 408.5 s (tablets), compared to a baseline of 387.3 s. Ischemic burden decreased to about -4.0 mm with both forms, compared to -7.5 mm at baseline (ANOVA: p = 0.003). The ischemic time improved to 137.2 s (spray) or 152.9 s (tablets), compared to 253.4 s at baseline (ANOVA: p = 0.005). Patients taking tablets experienced more episodes of hypotension and/or headache compared to patients taking the spray. Nitrolingual-Spray is as effective and safe as NTG tablets for the treatment of symptomatic coronary heart disease. Copyright (C) 2000 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033798321&doi=10.1159%2f000007017&partnerID=40&md5=517872e74bb0cb0bbbcfae430b6d2bef https://scholars.lib.ntu.edu.tw/handle/123456789/514921 |
ISSN: | 0008-6312 | DOI: | 10.1159/000007017 | SDG/關鍵字: | glyceryl trinitrate; nitrolingual spray; adult; aerosol; aged; article; clinical article; clinical trial; controlled clinical trial; controlled study; coronary artery disease; crossover procedure; drug efficacy; drug safety; exercise test; female; headache; human; hypotension; male; priority journal; randomized controlled trial; tablet; treadmill exercise; vertigo |
顯示於: | 醫學系 |
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