https://scholars.lib.ntu.edu.tw/handle/123456789/514971
標題: | Urine hemojuvelin in cats with naturally occurring kidney disease | 作者: | Jing, H. Hsu, W.-L. VIN-CENT WU Tsai, H.-J. Tsai P.-S.J. Tsai, P.-S.J. TAI-SHUAN LAI YA-JANE LEE PEI-SHIUE TSAI |
公開日期: | 2020 | 出版社: | Blackwell Publishing Inc. | 卷: | 34 | 期: | 3 | 起(迄)頁: | 1222-1230 | 來源出版物: | Journal of Veterinary Internal Medicine | 摘要: | Background: Soluble-type hemojuvelin in serum and urine has been shown to be a biomarker in humans for chronic kidney disease (CKD) and acute kidney injury (AKI). No similar research has been conducted on cats. Objective: Urine hemojuvelin (u-hemojuvelin) can be used as a clinical indicator for cats with various renal diseases. Animals: Eighteen healthy cats, 10 cats with AKI, 21 cats with acute-on-chronic kidney injury (ACKI), and 45 cats with CKD were enrolled. Methods: The expression profile of u-hemojuvelin was assessed by Western blot analysis, whereas the u-hemojuvelin concentration was measured using an in-house sandwich ELISA. Each cat's u-hemojuvelin-to-creatinine ratio (UHCR) also was determined. Results: Significant differences were found in both u-hemojuvelin concentration and UHCR between the control cats and the other cats (AKI, CKD, ACKI). Both u-hemojuvelin and UHCR had high areas under the receiver operator curve (AUROC) for diagnoses of AKI (u-hemojuvelin, 0.885; UHCR, 0.982), CKD (hemojuvelin, 0.869; UHCR, 0.959), and ACKI (hemojuvelin, 0.910; UHCR, 1). Late stage (International Renal Interest Society, IRIS stages 3 and 4) CKD cats had significantly higher u-hemojuvelin concentration and UHCR than did early stage cats (IRIS stages 1 and 2). Both u-hemojuvelin and UHCR were significantly correlated with high blood urea nitrogen, plasma creatinine, and plasma phosphate concentrations and with low hematocrit (Hct), red blood cell (RBC) count, and plasma albumin concentration. The UHCR values were also significantly correlated with white blood cell count in blood. Conclusion: Both u-hemojuvelin and UHCR potentially can serve as diagnostic indicators for a range of renal diseases in cats. ? 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083832517&doi=10.1111%2fjvim.15781&partnerID=40&md5=6391b45e67b2cf9c47744844169fc56a https://scholars.lib.ntu.edu.tw/handle/123456789/514971 |
ISSN: | 0891-6640 | DOI: | 10.1111/jvim.15781 | SDG/關鍵字: | albumin; biological marker; creatinine; hemojuvelin; nitrogen; phosphate; urea; biological marker; glycosylphosphatidylinositol anchored protein; hemochromatosis protein; acute kidney failure; acute on chronic kidney injury; albumin blood level; animal experiment; Article; cat disease; chronic kidney failure; controlled study; creatinine blood level; creatinine urine level; enzyme linked immunosorbent assay; erythrocyte count; female; gene expression profiling; hematocrit; kidney disease; leukocyte count; male; nonhuman; phosphate blood level; protein urine level; receiver operating characteristic; relative density; urea nitrogen blood level; uremia; urine sampling; Western blotting; animal; cat; cat disease; urine; veterinary medicine; Acute Kidney Injury; Animals; Biomarkers; Cat Diseases; Cats; Female; GPI-Linked Proteins; Hemochromatosis Protein; Male; Renal Insufficiency, Chronic |
顯示於: | 醫學系 |
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