https://scholars.lib.ntu.edu.tw/handle/123456789/515078
標題: | Hypokalemia correlated with arterial stiffness but not microvascular endothelial function in patients with primary aldosteronism | 作者: | Chang Y.-Y. Chen A. YING-HSIEN CHEN CHI-SHENG HUNG VIN-CENT WU Lin Y.-H. YEN-HUNG LIN YI-LWUN HO KWAN-DUN WU |
公開日期: | 2015 | 出版社: | SAGE Publications Ltd | 卷: | 16 | 期: | 2 | 起(迄)頁: | 353-359 | 來源出版物: | JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | 摘要: | Introduction: Hypokalemia in primary aldosteronism (PA) patients correlates with higher levels of cardiovascular events and altered left ventricular geometry. However, the influence of aldosterone on microvascular endothelial function and the effect of hypokalemia on the vascular structure still remain unclear. Objectives: We investigated the peripheral arterial functions, including the endothelial function of microvasculature and arterial stiffness in PA and essential hypertension (EH) patients, and the correlation between hypokalemia and peripheral arterial function among PA patients. Methods: Twenty patients diagnosed as EH and 37 patients with PA were enrolled in this study. Reactive hyperemia index (RHI) and the augmentation index (AI) were obtained by non-invasive peripheral arterial tonometry. Results: Twenty EH patients and a total of 37 PA patients, including 21 patients with normokalemia and 16 patients with hypokalemia, were enrolled and divided into groups 1, 2 and 3 respectively. PA patients had significantly higher AI (p=0.024) but not RHI than EH patients. RHI showed no difference between groups 1, 2 and 3. Group 3 had higher AI than either group 1 or group 2. In the whole study population, serum potassium level, after multivariate regression analysis testing, was the only factor associated with AI (?= -0.102; p=0.002). In PA patients, serum potassium level was the only significant factor correlated with AI. (r= -0.458; p=0.004) Conclusions: PA patients had higher arterial stiffness but comparable microvascular endothelial function to EH patients. Hypokalemia correlated with arterial stiffness but not microvascular endothelial function in PA patients. ? 2015 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930889560&doi=10.1177%2f1470320314524996&partnerID=40&md5=ac6af39354a42e6986d9b328a8ff43bb https://scholars.lib.ntu.edu.tw/handle/123456789/515078 |
ISSN: | 1470-3203 | DOI: | 10.1177/1470320314524996 | SDG/關鍵字: | potassium; adult; arterial stiffness; Article; capillary endothelial cell; cell function; controlled study; correlational study; disease association; essential hypertension; female; human; hyperemia; hypokalemia; major clinical study; male; peripheral arterial tonometry; potassium blood level; primary hyperaldosteronism; prospective study; arterial stiffness; complication; hyperaldosteronism; hypokalemia; manometry; microvasculature; middle aged; multivariate analysis; pathophysiology; physiology; regression analysis; vascular endothelium; Adult; Endothelium, Vascular; Female; Humans; Hyperaldosteronism; Hypokalemia; Male; Manometry; Microvessels; Middle Aged; Multivariate Analysis; Regression Analysis; Vascular Stiffness |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。