https://scholars.lib.ntu.edu.tw/handle/123456789/515196
標題: | Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease | 作者: | YEN-HUNG LIN Pao K.-Y. WEI-SHIUNG YANG VIN-CENT WU Chen Y.-J. Tsai W.-S. Tsai I.-J. I-JUNG TSAI Hwang J.-J. HWANG, JUEY-JEN |
公開日期: | 2008 | 卷: | 46 | 期: | 1 | 起(迄)頁: | 125-130 | 來源出版物: | Clinical Chemistry and Laboratory Medicine | 摘要: | Background: Obesity and homocysteine are important risk factors for cardiovascular disease. The relation between pattern of obesity and homocysteine is unclear. The objective of this study was to investigate the relation between pattern of obesity and plasma total homocysteine (tHcy) level in male patients with coronary artery disease (CAD). Methods: A total of 63 male patients (mean age 66.2 years) with angiographically documented CAD were enrolled. Overnight fasting blood samples were measured for plasma tHcy, serum folic acid and serum vitamin B12 levels. Anthropometric measurements included waist-to-hip ratio (WHR) and body mass index (BMI). Results: The mean WHR was 0.90±0.05, mean BMI 24.6±3.3 kg/m2 and the mean plasma tHcy level 11.6±3.2 μmol/L. In univariate analysis, plasma tHcy level correlated significantly with serum vitamin B12 level, serum folic acid level, WHR, estimated creatinine clearance, aspirin use and fibrate use. There was no significant association between plasma tHcy level and BMI. In multivariate analysis, only WHR (β-value 22.263, p<0.001), serum level of vitamin B12 (β-value -0.004, p=0.003), estimated creatinine clearance (β-value -4.154, p=0.003) and use of fibrates (β-value 2.307, p=0.031) were independent predictors of plasma tHcy level. Conclusions: WHR, but not BMI, is a strong independent predictor of plasma tHcy level in male patients with CAD. ? 2008 by Walter de Gruyter. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-38349016466&doi=10.1515%2fCCLM.2008.016&partnerID=40&md5=21ffba19361d469ca2078866e93703a5 https://scholars.lib.ntu.edu.tw/handle/123456789/515196 |
ISSN: | 1434-6621 | DOI: | 10.1515/CCLM.2008.016 | SDG/關鍵字: | acetylsalicylic acid; creatinine; cyanocobalamin; fibric acid derivative; folic acid; homocysteine; insulin; adult; aged; amino acid blood level; angiography; article; blood sampling; body mass; controlled study; coronary artery disease; correlation analysis; drug blood level; human; insulin blood level; major clinical study; male; obesity; priority journal; univariate analysis; vitamin blood level; waist hip ratio; Aged; Biological Markers; Body Mass Index; Coronary Artery Disease; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Obesity; Risk Factors; Vitamin B 12; Waist-Hip Ratio |
顯示於: | 醫學系 |
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