https://scholars.lib.ntu.edu.tw/handle/123456789/515756
標題: | Effect of a Hepatitis A Vaccination Campaign During a Hepatitis A Outbreak in Taiwan, 2015-2017: A Modeling Study | 作者: | KUAN-YIN LIN HSIN-YUN SUN Chen Y.-H. Lo Y.-C. SZU-MIN HSIEH WANG-HUEI SHENG YU-CHUNG CHUANG SUNG-CHING PAN ARISTINE CHENG CHIEN-CHING HUNG CHI-TAI FANG SHAN-CHWEN CHANG |
公開日期: | 2020 | 出版社: | NLM (Medline) | 卷: | 70 | 期: | 8 | 起(迄)頁: | 1742-1749 | 來源出版物: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 摘要: | Background. Beginning from 2015-2016, unprecedented large outbreaks of acute hepatitis A that predominantly affected men who have sex with men (MSM) reemerged across the continents. We assessed the impact of an early initiated hepatitis A virus (HAV) vaccination campaign that targeted MSM living with human immunodeficiency virus (HIV) during the 2015-2017 hepatitis A outbreak in Taiwan. Methods. First, we ascertained the effectiveness of HAV vaccination for MSM living with HIV using a nested case-control study of 1470 persons living with HIV who were initially HAV-seronegative. We then fitted a model of HAV transmission among MSM, risk-structured by HIV status, to the actual epidemic curve of reported acute hepatitis A cases in Taiwan during 2015-2017. Results. Fifty-five cases of acute hepatitis A were matched to 220 controls. Single-dose and 2-dose HAV vaccination provided protection rates of 96.1% and 97.8% among recipient MSM living with HIV, respectively. Model fitting yielded basic reproductive number estimates of 7.26 (MSM living with HIV) and 3.04 (MSM not living with HIV). In a counterfactual scenario without an HAV vaccination campaign, the outbreak would have involved 7153 hepatitis A cases during 2015-2017 in contrast to the 1352 that were observed. We therefore estimated that the HAV vaccination campaign averted 80.7% (sensitivity analysis, 48.8%-92.7%) of acute hepatitis A cases that would otherwise have occurred by the end of 2017. Conclusions. The early initiated HAV vaccination campaign, which targeted MSM living with HIV, very effectively curtailed the 2015-2017 hepatitis A outbreak in Taiwan. ? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078738750&doi=10.1093%2fcid%2fciz471&partnerID=40&md5=169713c1f5ba1fea4a873b230271f2e5 https://scholars.lib.ntu.edu.tw/handle/123456789/515756 |
ISSN: | 1537-6591 | DOI: | 10.1093/cid/ciz471 | SDG/關鍵字: | case control study; epidemic; hepatitis A; human; Human immunodeficiency virus infection; male; male homosexuality; preventive health service; sexual and gender minority; Taiwan; vaccination; Case-Control Studies; Disease Outbreaks; Hepatitis A; HIV Infections; Homosexuality, Male; Humans; Immunization Programs; Male; Sexual and Gender Minorities; Taiwan; Vaccination |
顯示於: | 醫學系 |
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