https://scholars.lib.ntu.edu.tw/handle/123456789/515811
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SUNG-CHING PAN | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | Huang P.-F. | en_US |
dc.contributor.author | Chen M.-Y. | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Sung-Ching Pan;Hsieh S.-M.;Hung C.-C.;Huang P.-F.;Chen M.-Y.;Chang S.-C. | - |
dc.date.accessioned | 2020-09-30T02:30:20Z | - |
dc.date.available | 2020-09-30T02:30:20Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-14744295298&partnerID=40&md5=b12bb6c5731ab116348ad8aaef2e2c0f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/515811 | - |
dc.description.abstract | This study evaluated the feasibility of reducing the indinavir (IDV) dosage in Taiwanese patients receiving the standard IDV/ritonavir (RTV) dosage of 800/100 mg twice a day who had undetectable plasma human immunodeficiency virus type 1 (HIV-1) RNA but had developed IDV-related toxicities. After dosage reduction to IDV/RTV 600/100 mg twice a day, the dose-related toxicity decreased and plasma HIV RNA remained undetectable at 24 weeks post-switch in all patients. The maximal plasma concentration (Cmax) and area under the plasma concentration-time curve of IDV decreased significantly (median, 6.3 vs 4.3 μg/mL and 1892 vs 1292 μg·min/mL, P=0.01 and 0.001, respectively) but the minimal plasma concentration remained at a similar level (median, 1.0 vs 0.8 μg/mL, p=0.12). This study found that the reduction in the dosage of IDV in HIV-1 infected patients receiving the standard IDV/RTV regimen guided by therapeutic drug monitoring decreased the Cmax, dose-related toxicity and medical cost without compromising viral control. | en_US |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antiretrovirus agent; CD4 antigen; indinavir; proteinase inhibitor; virus RNA; adult; article; clinical article; dose response; dose time effect relation; drug blood level; drug dose reduction; drug monitoring; hair loss; hematuria; high performance liquid chromatography; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; leukocyte count; low back pain; nausea; nephrolithiasis; skin disease; Taiwan; treatment outcome; virus infection; virus load; Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; HIV-1; Humans; Indinavir; Pilot Projects | - |
dc.title | Dose reduction for the management of indinavir-related toxicity in human immunodeficiency virus type 1-infected patients in Taiwan: Clinical and pharmacokinetic assessment | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 15692624 | - |
dc.identifier.scopus | 2-s2.0-14744295298 | - |
dc.relation.pages | 31-34 | en_US |
dc.relation.journalvolume | 38 | en_US |
dc.relation.journalissue | 1 | en_US |
item.openairetype | journal article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0003-3154-6690 | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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