https://scholars.lib.ntu.edu.tw/handle/123456789/516892
標題: | Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic PD patients | 作者: | Ho L.-C. CHUNG-JEN YEN CHIA-TER CHAO CHIH-KANG CHIANG JENQ-WEN HUANG KUAN-YU HUNG |
公開日期: | 2015 | 出版社: | Nature Publishing Group | 卷: | 5 | 起(迄)頁: | 12811 | 來源出版物: | Scientific Reports | 摘要: | Factors associated with increased visceral fat area (VFA) have been well documented in the general population but rarely explored in nondiabetic individuals on peritoneal dialysis (PD). As glycosylated hemoglobin (HbA1c) is positively correlated with VFA in diabetic patients, we hypothesized that the same correlation would exist in nondiabetic PD patients. We enrolled 105 nondiabetic patients who had undergone chronic PD for more than 3 months. Each subject underwent an abdominal computed tomography (CT) scan, and the umbilicus cut was analyzed for VFA. VFA values, corrected for body mass index and subjected to natural logarithm transformations, were examined to determine whether they were correlated with HbA1c and other parameters. PD dialysates prescribed at the time of enrollment were recorded to calculate glucose load. We found that when 105 nondiabetic PD patients were classified according to tertiles of HbA1c, higher HbA1c was associated with larger VFA. Multiple linear regression analysis revealed that HbA1c was an independent determinant of VFA, while glucose load and other PD-specific factors were not. In summary, HbA1c, but not PD-related glucose load, was positively correlated with VFA in nondiabetic PD patients, suggesting clinical utility of HbA1c in the PD population. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938651735&doi=10.1038%2fsrep12811&partnerID=40&md5=87897aa0263a17a01916c061866aa7be https://scholars.lib.ntu.edu.tw/handle/123456789/516892 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep12811 | SDG/關鍵字: | biological marker; dialysis fluid; glucose; glycosylated hemoglobin; hemoglobin A1c protein, human; adult; aged; chemistry; chronic kidney failure; diagnostic imaging; female; glycosylation; human; intraabdominal fat; male; metabolism; middle aged; obesity; pathology; peritoneal dialysis; x-ray computed tomography; Adult; Aged; Biomarkers; Dialysis Solutions; Female; Glucose; Glycosylation; Hemoglobin A, Glycosylated; Humans; Intra-Abdominal Fat; Male; Middle Aged; Obesity; Peritoneal Dialysis; Renal Insufficiency, Chronic; Tomography, X-Ray Computed |
顯示於: | 醫學系 |
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