https://scholars.lib.ntu.edu.tw/handle/123456789/516906
標題: | Lean Body Mass Predicts Long-Term Survival in Chinese Patients on Peritoneal Dialysis | 作者: | JENQ-WEN HUANG Lien Y.-C. Wu H.-Y. CHUNG-JEN YEN Pan C.-C. Hung T.-W. CHI-TING SU CHIH-KANG CHIANG HUI-TENG CHENG KUAN-YU HUNG |
公開日期: | 2013 | 卷: | 8 | 期: | 1 | 起(迄)頁: | e54976 | 來源出版物: | PLoS ONE | 摘要: | Background: Reduced lean body mass (LBM) is one of the main indicators in malnutrition inflammation syndrome among patients on dialysis. However, the influence of LBM on peritoneal dialysis (PD) patients' outcomes and the factors related to increasing LBM are seldom reported. Methods: We enrolled 103 incident PD patients between 2002 and 2003, and followed them until December 2011. Clinical characteristics, PD-associated parameters, residual renal function, and serum chemistry profiles of each patient were collected at 1 month and 1 year after initiating PD. LBM was estimated using creatinine index corrected with body weight. Multiple linear regression analysis, Kaplan-Meier survival analysis, and Cox regression proportional hazard analysis were used to define independent variables and compare survival between groups. Results: Using the median LBM value (70% for men and 64% for women), patients were divided into group 1 (n = 52; low LBM) and group 2 (n = 51; high LBM). Group 1 patients had higher rates of peritonitis (1.6 vs. 1.1/100 patient months; p<0.05) and hospitalization (14.6 vs. 9.7/100 patient months; p<0.05). Group 1 patients also had shorter overall survival and technique survival (p<0.01). Each percentage point increase in LBM reduced the hazard ratio for mortality by 8% after adjustment for diabetes, age, sex, and body mass index (BMI). Changes in residual renal function and protein catabolic rate were independently associated with changes in LBM in the first year of PD. Conclusions: LBM serves as a good parameter in addition to BMI to predict the survival of patients on PD. Preserving residual renal function and increasing protein intake can increase LBM. © 2013 Huang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872876246&doi=10.1371%2fjournal.pone.0054976&partnerID=40&md5=fd636a0fde527bba170ad9de8a256b84 https://scholars.lib.ntu.edu.tw/handle/123456789/516906 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0054976 | SDG/關鍵字: | albumin; cholesterol; creatinine; glucose; nitrogen; triacylglycerol; urea; age distribution; aged; albumin blood level; article; body weight; Chinese; clinical evaluation; controlled study; creatinine blood level; creatinine clearance; diabetes mellitus; female; glucose blood level; human; kidney function; lean body weight; length of stay; long term survival; major clinical study; male; mortality; outcome assessment; overall survival; peritoneal dialysis; peritonitis; protein degradation; sex difference; survival rate; treatment duration; urea nitrogen blood level; Adult; Aged; Asian Continental Ancestry Group; Body Mass Index; Body Weight; China; Creatinine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peritoneal Dialysis; Prognosis; Proportional Hazards Models |
顯示於: | 醫學系 |
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