https://scholars.lib.ntu.edu.tw/handle/123456789/517100
標題: | The association between new onset atrial fibrillation and incident cancer—a nationwide cohort study | 作者: | CHI-SHENG HUNG CHIA-HSUIN CHANG JOU-WEI LIN YI-LWUN HO MING-FONG CHEN |
公開日期: | 2018 | 出版社: | Public Library of Science | 卷: | 13 | 期: | 6 | 起(迄)頁: | e0199901 | 來源出版物: | PLoS ONE | 摘要: | A recent analysis showed an association with new onset atrial fibrillation (NOAF) and incident cancer among women. We aimed to examine the risk of cancer among patients with NOAF in general population. A retrospective cohort of 5130 patients with NOAF was identified from a random sample of one million subjects between 2005 and 2010 from Taiwan National Health Insurance Research Database. The standard incidence ratio of incident cancer and hazard ratios were calculated by modeling cumulative incidence with competing risk of death. During a mean follow-up duration of 3.4 years, 330 patients developed cancer. The standard incidence ratio of all malignancies was 1.41 (95% confidence interval 1.26–1.57), suggesting a 41% increase in cancer risk compared with the general population. The risk of cancer was higher among men or the elderly with NOAF after adjusting for confounding factors and after considering the competing risk of death. The risk of cancer was not associated with CHA2DS2–VASc score (p = 0.32) among patients with NOAF. In conclusion, patients with NOAF were associated with a higher risk of cancer. Within this group, the risk of ischemic stroke (in terms of CHADS2-VASc score) did not reflect the risk of incident cancer. ? 2018 Hung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049188211&doi=10.1371%2fjournal.pone.0199901&partnerID=40&md5=63d3d58ab8ca2c87c97cc46ab05b079f https://scholars.lib.ntu.edu.tw/handle/123456789/517100 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0199901 | SDG/關鍵字: | aged; Article; atrial fibrillation; breast cancer; cancer diagnosis; cancer incidence; cancer risk; CHA2DS2-VASc score; clinical outcome; cohort analysis; colon cancer; comparative study; controlled study; disease association; female; follow up; human; liver cancer; lung cancer; major clinical study; male; mortality risk; retrospective study; Taiwan; age; atrial fibrillation; brain ischemia; cerebrovascular accident; incidence; middle aged; mortality; neoplasm; randomized controlled trial; risk factor; sex factor; very elderly; Age Factors; Aged; Aged, 80 and over; Atrial Fibrillation; Brain Ischemia; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Neoplasms; Risk Factors; Sex Factors; Stroke |
顯示於: | 醫學系 |
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