https://scholars.lib.ntu.edu.tw/handle/123456789/517115
標題: | Effectiveness of pneumococcal conjugate vaccines of different valences against invasive pneumococcal disease among children in Taiwan: A nationwide study | 作者: | Su W.-J. Lo H.-Y. CHIA-HSUIN CHANG LUAN-YIN CHANG Chiu C.-H. PING-ING LEE CHUN-YI LU Hsieh Y.-C. Lai M.-S. Lin T.-Y. |
公開日期: | 2016 | 出版社: | Lippincott Williams and Wilkins | 卷: | 35 | 期: | 4 | 起(迄)頁: | e124-e133 | 來源出版物: | Pediatric Infectious Disease Journal | 摘要: | Background: For the scarcity of data, we investigated the vaccine effectiveness (VE) of the combined use of pneumococcal conjugate vaccines (PCVs) of different valences against invasive pneumococcal disease (IPD) in children. Methods: We conducted a matched case-control study using the national IPD surveillance database and the national vaccination registry. Four agematched, gender-matched and neighborhood-matched controls were identified for each incident IPD case ?5 years with disease onsets between October 2007 and December 2013. Conditional logistic regression was used to assess VE against all serotype and serotype 19A IPD. Results: In 523 cases (median age: 28.5 months; range: 2.0-69.4 months) and 2086 controls (28.7; 2.2-70.1), a similar VE against all-serotype IPD was found between PCV13 (76%; 61-85%) and combined 7-valent PCV (PCV7)/10-valent PCV (PCV10) plus PCV13 (78%; 56-89%). The VE for PCV7/PCV10 was slightly lower (48%; 32-60%). Regarding serotype 19A, a significantly reduced risk was observed for both PCV13 (82%; 63-91%) and combined PCV7/PCV10 plus PCV13 (87%; 61-96%). PCV7/PCV10 had only a borderline protective association (31%; 4-51%). For children receiving PCV13 alone, VE against all-serotype IPD did not differ between starting the dosing at ?2 (78%; 56-89%) or <2 (74%; 51-87%) years of age. VE was 81% (69-88%) within 6 months of the last dose of PCV and 19% (95% CI: -21 to 45%) after 2 years. Conclusions: PCVs are effective against IPD during immunization with either the same or with a mixed series, but protection might be differential over time. Copyright ? 2015 Wolters Kluwer Health, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961958115&doi=10.1097%2fINF.0000000000001054&partnerID=40&md5=b6ea77c7da1c059bb3a81418c7470f35 https://scholars.lib.ntu.edu.tw/handle/123456789/517115 |
ISSN: | 0891-3668 | DOI: | 10.1097/INF.0000000000001054 | SDG/關鍵字: | Pneumococcus vaccine; 10-valent pneumococcal conjugate vaccine; 13-valent pneumococcal vaccine; Pneumococcus vaccine; vaccine; Article; case control study; child; controlled study; cross protection; data base; drug efficacy; female; human; male; pneumococcal infection; preschool child; priority journal; register; serotype; Taiwan; vaccination; classification; factual database; health survey; immunization; immunology; infant; outcome assessment; Pneumococcal Infections; Streptococcus pneumoniae; Case-Control Studies; Child, Preschool; Databases, Factual; Female; Heptavalent Pneumococcal Conjugate Vaccine; Humans; Immunization Schedule; Infant; Male; Outcome Assessment (Health Care); Pneumococcal Infections; Pneumococcal Vaccines; Population Surveillance; Serogroup; Streptococcus pneumoniae; Taiwan; Vaccines, Conjugate |
顯示於: | 醫學系 |
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