https://scholars.lib.ntu.edu.tw/handle/123456789/517343
標題: | In vivo detection of UV-induced acute skin effects using optical coherence tomography | 作者: | Chen W.-J. Chang Y.-Y. Shen S.-C. Tzeng Y.-L. HSIANG-CHIEH LEE Yang C.-H. Tsai M.-T. |
公開日期: | 2018 | 卷: | 9 | 期: | 9 | 起(迄)頁: | 4235-4245 | 來源出版物: | Biomedical Optics Express | 摘要: | Ultraviolet (UV) rays have been identified as a carcinogen with long-term irradiation and are an important risk factor for skin cancer. Here, we report the use of optical coherence tomography/optical coherence tomography angiography (OCT/OCTA) to study acute UV-induced effects on skin in vivo. To understand the relationship between the acute effects and irradiated UV power density, three groups were irradiated with different power densities in our experiments. Furthermore, the same skin area was repeatedly scanned with OCT during UV irradiation to investigate the progress of the induced acute effects and after irradiation for observation of skin recovery. Subsequently, the OCT/OCTA results were quantitatively analyzed to acquire skin thickness and blood-vessel density for comparison. UV-induced acute effects on morphology and microcirculation can be identified from OCT/OCTA results, which showed the increases in the skin thickness and blood-vessel density and even severe damage types such as blisters. The results of quantitative analyses also illustrated that the severity of damage induced by UV irradiation can be distinguished and the skin recovery can be monitored with OCT. Our results indicate that OCT can be a promising tool for early detection of UV-induced acute skin damage. ? 2018 Optical Society of America. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052733061&doi=10.1364%2fBOE.9.004235&partnerID=40&md5=494326199de2d4fec1e2c6967a7c995d https://scholars.lib.ntu.edu.tw/handle/123456789/517343 |
DOI: | 10.1364/BOE.9.004235 | SDG/關鍵字: | Blood vessels; Damage detection; Dermatology; Irradiation; Microcirculation; Coherence tomography; Power densities; Risk factors; Skin cancers; Skin in vivo; Skin thickness; Ultraviolet rays; UV irradiation; Optical tomography; animal experiment; Article; blister; blood flow; dermatitis; in vivo study; microcirculation; mouse; nonhuman; optical coherence tomography; skin defect; skin swelling; skinfold thickness; ultraviolet radiation |
顯示於: | 電機工程學系 |
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