https://scholars.lib.ntu.edu.tw/handle/123456789/517688
標題: | Azathioprine-induced severe bone marrow toxicity - A report of 3 cases | 作者: | Lo L.-K. Hung C.-M. Chen Y.-F. Ko W.-C. TSEN-FANG TSAI CHIA-YU CHU |
公開日期: | 2009 | 卷: | 27 | 期: | 1 | 起(迄)頁: | 44-51 | 來源出版物: | Dermatologica Sinica | 摘要: | Dermatologists have been using azathioprine as a "steroid sparing agent" for the treatment of various dermatoses including photodermatoses, immunobullous diseases, psoriasis and eczematous diseases. However, in Taiwan, the currently approved indications of azathioprine include only adjunct therapy of renal transplant, systemic lupus erythematosus, severe rheumatoid arthritis, and leukemia. Owing to the off-label nature of azathiopine use in most dermatological practice, clinical vigilance must be taken. We herein report 3 cases of severe bone marrow toxicity after the use of azathioprine and discuss the pathogenesis and suggestive management of this rare complication. The first patient had prolonged pancytopenia lasting for 3 months despite immediate azathioprine withdrawal and 2 consecutive doses of granulocyte colony-stimulating factor. The full blood count of the other two patients had returned to normal one week after treatment. The result of genotyping of three patients to detect most prevalent mutant allele (TPMT*3C) was negative. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-63049131554&partnerID=40&md5=c418fd757917992333e478a4dcc4d1fc https://scholars.lib.ntu.edu.tw/handle/123456789/517688 |
ISSN: | 1027-8117 | SDG/關鍵字: | antibiotic agent; antihistaminic agent; azathioprine; corticosteroid; granulocyte colony stimulating factor; prednisolone; valaciclovir; adult; aged; article; atopic dermatitis; blood analysis; bone marrow biopsy; bone marrow suppression; bone marrow toxicity; bullous pemphigoid; case report; disease severity; drug dose increase; drug induced disease; drug withdrawal; dyspnea; febrile neutropenia; fever; genotype; human; immunopathology; jaundice; laboratory test; liver toxicity; male; prurigo; symptomatology; thrombocytopenia; treatment failure |
顯示於: | 醫學系 |
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