https://scholars.lib.ntu.edu.tw/handle/123456789/517777
標題: | Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014 | 作者: | Ma I.-H. FUNG-RONG HU I-JONG WANG WEI-LI CHEN Hsu Y.-J. HSIAO-SANG CHU CHANG-TSU YUAN YU-CHIH HOU |
公開日期: | 2019 | 卷: | 118 | 期: | 4 | 起(迄)頁: | 776-782 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: To describe the clinical and histologic characteristics of ocular surface squamous neoplasia (OSSN) and evaluate factors significant in recurrence at a university hospital in North Taiwan. Methods: Patient charts, clinical features, and pathology records were retrospectively reviewed in patients with pathology-proved OSSN from January, 1994 to December, 2014. Clinicopathologic correlation was analyzed. Results: Thirty-six patients were recruited. Mean age was 63.4 ± 13.0 (ranging from 23 to 87) years old. OSSN was predominant in men (21/36). Clinical appearances included papilliform in 17 eyes, gelatinous in 11 eyes, leukoplakic in 3 eyes, and 5 eyes in corneal intraepithelial neoplasia (CIN). Of 31 conjunctival OSSN, there were 4 in CIN I, 11 in CIN II, 13 in CIN III, and 3 in squamous cell carcinoma. Superior location was associated with higher-grade OSSN. Although statistical analysis was not significant, papilliform and multifocal lesions showed a trend of high-grade OSSN. The stages of tumor were 4, 5, 26, and 1 eye(s) in T1 to T4, respectively. Recurrence of disease occurred in 9 cases (25%) with mean recurrence time of 20.6 (range: 4 to 65) months. Multifocal lesion has a higher tendency for recurrence. Conclusion: Superior location was associated with high-grade OSSN, and papilliform OSSN might have a tendency of severe and invasive lesions. Multifocal lesions might be associated with higher-grade OSSN and higher recurrence rates. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053903298&doi=10.1016%2fj.jfma.2018.09.001&partnerID=40&md5=5f5febf0648fa74abef5d494d985b9fa https://scholars.lib.ntu.edu.tw/handle/123456789/517777 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2018.09.001 | SDG/關鍵字: | alpha2b interferon; mitomycin; alpha interferon; antineoplastic agent; mitomycin; adjuvant chemotherapy; adjuvant therapy; adult; aged; Article; cancer patient; cancer recurrence; cancer surgery; clinical article; clinical feature; conjunctiva tumor; cryotherapy; excision; eye cancer; eye surgery; female; human; leukoplakia; male; ocular surface disease; ocular surface squamous neoplasia; ophthalmologist; recurrent disease; retrospective study; squamous cell carcinoma; Taiwan; tumor volume; university hospital; conjunctiva tumor; cornea; cornea disease; hyperplasia; middle aged; pathology; squamous cell carcinoma; tumor recurrence; very elderly; young adult; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Conjunctival Neoplasms; Cornea; Corneal Diseases; Cryotherapy; Female; Hospitals, University; Humans; Hyperplasia; Interferon-alpha; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Ophthalmologic Surgical Procedures; Retrospective Studies; Taiwan; Young Adult |
顯示於: | 醫學系 |
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