https://scholars.lib.ntu.edu.tw/handle/123456789/517809
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIEN-CHIA SU | en_US |
dc.contributor.author | I-JONG WANG | en_US |
dc.contributor.author | WEI-LI CHEN | en_US |
dc.contributor.author | Lin C.-P. | en_US |
dc.contributor.author | His B. | en_US |
dc.contributor.author | FUNG-RONG HU | en_US |
dc.creator | Su C.-C.;Wang I.-J.;Wei-Li Chen;Lin C.-P.;His B.;Hu F.-R. | - |
dc.date.accessioned | 2020-10-22T07:41:49Z | - |
dc.date.available | 2020-10-22T07:41:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1442-6404 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878916254&doi=10.1111%2fj.1442-9071.2012.02888.x&partnerID=40&md5=212ac4ecf52af629256c1b2aa966651f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/517809 | - |
dc.description.abstract | Background: To report seven cases diagnosed as cytomegalovirus endotheliitis and treated with topical 2% ganciclovir following penetrating keratoplasty. Design: A retrospectively comparative case series. Participants: A retrospective interventional case series, including seven eyes of seven patients with cytomegalovirus endotheliitis after penetrating keratoplasty. Methods: Clinical and immunological characteristics were studied in seven penetrating keratoplasty cases with positive quantitative polymerase chain reaction results for cytomegalovirus DNA from aqueous taps and treated with topical 2% ganciclovir. Main Outcome Measures: Clinical features and responses to topical 2% ganciclovir. Results: Seven immunocompetent patients experienced acute anterior inflammation with graft oedema and pigmented keratic precipitates after penetrating keratoplasty. Their immunological profiles showed immunoglobulin G cytomegalovirus (+) and immunoglobulin M cytomegalovirus (-) in all cases. Topical 2% ganciclovir was prescribed every 2 to 3h daily as induction therapy and every 4h as long-term maintenance therapy. All cases had undetectable cytomegalovirus DNA after follow-up aqueous taps. Topical 2% ganciclovir preserved endothelium of cytomegalovirus-infected grafts at early stage and also provided a steady anticytomegalovirus environment for further regrafting in failed grafts at late stage. Acute inflammation reactivated in two cases and was suppressible by steroid under topical ganciclovir. No delayed re-epithelialization and any toxicity were observed. To date, no case treated in this way had displayed cytomegalovirus recurrence. Conclusions: Continuous topical 2% ganciclovir and a topical steroid adjusted by anterior inflammation are suggested after penetrating keratoplasty in all cases with cytomegalovirus endotheliitis to prevent cytomegalovirus recurrence. ? 2012 The Authors. Clinical and Experimental Ophthalmology ? 2012 Royal Australian and New Zealand College of Ophthalmologists. | - |
dc.relation.ispartof | Clinical and Experimental Ophthalmology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ganciclovir; immunoglobulin G; immunoglobulin M; virus DNA; adult; aged; antiviral therapy; aqueous humor; article; clinical article; clinical feature; comparative study; cytomegalovirus corneal endotheliitis; endothelium; endothelium cell; epithelization; female; follow up; human; intervention study; maintenance therapy; male; penetrating keratoplasty; polymerase chain reaction; recurrent disease; retrospective study; treatment duration; treatment response; virus keratitis; Administration, Topical; Aged; Antibodies, Viral; Antiviral Agents; Aqueous Humor; Cell Count; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Endothelium, Corneal; Enzyme-Linked Immunosorbent Assay; Eye Infections, Viral; Female; Ganciclovir; Graft Survival; Humans; Keratitis; Keratoplasty, Penetrating; Male; Middle Aged; Postoperative Complications; Real-Time Polymerase Chain Reaction; Retrospective Studies | - |
dc.title | Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1442-9071.2012.02888.x | - |
dc.identifier.pmid | 23009154 | - |
dc.identifier.scopus | 2-s2.0-84878916254 | - |
dc.relation.pages | 339-347 | - |
dc.relation.journalvolume | 41 | - |
dc.relation.journalissue | 4 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Division of Pediatric Ophthalmology and Refraction | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Glaucoma | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Cornea | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Cornea | - |
crisitem.author.dept | Ophthalmology | - |
crisitem.author.dept | Ophthalmology-NTUH | - |
crisitem.author.dept | Division of Cornea | - |
crisitem.author.orcid | 0000-0002-9220-7599 | - |
crisitem.author.orcid | 0000-0002-3045-0614 | - |
crisitem.author.orcid | 0000-0002-1538-2414 | - |
crisitem.author.orcid | 0000-0002-2102-5317 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Ophthalmology-NTUH | - |
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