https://scholars.lib.ntu.edu.tw/handle/123456789/517839
標題: | The genetic effect on refractive error and anterior corneal aberration: Twin eye study | 作者: | Yeh L.-K. Chiu C.-J. Fong C.-F. I-JONG WANG WEI-LI CHEN CHUHSING KATE HSIAO Huang S.C.M. Shih Y.-F. FUNG-RONG HU Lin L.L.K. |
公開日期: | 2007 | 卷: | 23 | 期: | 3 | 起(迄)頁: | 257-265 | 來源出版物: | Journal of Refractive Surgery | 摘要: | PURPOSE: To investigate the role of heredity in determining refractive variables, anterior corneal curvature, and anterior corneal aberrations. METHODS: Thirty-three monozygotic and 10 dizygotic twin pairs were enrolled in this study. Corneal curvature, corneal astigmatism, and corneal topography were obtained from computerized videokeratoscope. The CTView program was used to compute anterior corneal aberrations from corneal height data of the videokeratoscope. Correlation analysis was performed to investigate the symmetry of the refractive error, corneal curvature, corneal astigmatism, and anterior corneal aberrations between right and left eyes of each twin pair. Heritability (h2) of these parameters was also calculated. RESULTS: Positive correlations were noted between right and left eyes for spherical power, total astigmatism, mean corneal curvature, and corneal astigmatism. In monozygotic twins, vertical coma, secondary vertical coma, spherical aberration, and secondary spherical aberration were moderately correlated. In dizygotic twins, vertical coma, secondary horizontal coma, and spherical aberration were moderately correlated. In unrelated controls, secondary vertical coma, secondary horizontal coma, and secondary spherical aberration were moderately correlated. Root-mean-square (RMS) of higher order aberrations (3rd to 6th orders), RMS of spherical aberration, and RMS of coma were moderately correlated between right and left eyes in all three groups. Heritability of spherical aberration, RMS of spherical aberration, and corneal astigmatism (h2=0.56, 0.44, and 0.46) were greater than those of refractive power, corneal curvature, and other higher order aberrations. CONCLUSIONS: These results suggest that corneal astigmatism and spherical aberration possess a greater genetic predisposition than those of other refractive errors and higher order aberrations. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947414495&doi=10.3928%2f1081-597x-20070301-08&partnerID=40&md5=6ef29086e3d5cd09f52be9b743ea0504 https://scholars.lib.ntu.edu.tw/handle/123456789/517839 |
ISSN: | 1081-597X | DOI: | 10.3928/1081-597x-20070301-08 | SDG/關鍵字: | adult; aged; article; astigmatism; clinical article; controlled study; cornea curvature; cornea disease; dizygotic twins; genetic predisposition; heredity; human; keratometry; keratoscopy; monozygotic twins; priority journal; refraction error |
顯示於: | 醫學系 |
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