https://scholars.lib.ntu.edu.tw/handle/123456789/517933
標題: | Dosage and duration of antipsychotic treatment in demented outpatients with agitation or psychosis | 作者: | YI-TING LIN TZUNG-JENG HWANG Shan J.-C. Chiang H.-L. Sheu Y.-H. HAI-GWO HWU |
公開日期: | 2015 | 卷: | 114 | 期: | 2 | 起(迄)頁: | 147-153 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: The USA Food and Drug Administration (FDA) issued warnings regarding the use of antipsychotics in patients with dementia in 2003 and 2005. We aimed to study the dose and duration of antipsychotic treatment in dementia, and to examine whether physicians' prescription behaviors changed after the FDA warnings. Methods: Medical charts of outpatients who had Alzheimer's disease, vascular dementia, or mixed dementia were reviewed. Patients must have achieved a clinically stable state for at least 4 weeks after receiving antipsychotic treatment for agitation or psychosis. Demographics, clinical correlates, and duration of antipsychotic treatment were compared among different antipsychotic groups. Because the quetiapine group had the largest sample size, the optimal dose and duration of quetiapine treatment were compared among three time periods (before 2003, 2003-2005, after 2005). Results: Stable state was achieved in 215 patients (80 had Alzheimer's disease, 117 vascular dementia, and 18 mixed dementia). Most patients (177) took quetiapine, 25 took risperidone, and 13 took sulpiride. The whole sample had a long total duration of antipsychotic treatment (median 525 days, mean 707 days). The median dose and total duration of antipsychotic treatment were 1.0. mg/day and 238 days for risperidone, 100. mg/day and 390 days for sulpiride, and 25. mg/day and 611 days for quetiapine, respectively. The optimal dose and total duration of quetiapine treatment decreased significantly after FDA warning in 2005, although the duration remained long. Conclusion: The optimal doses of antipsychotics were not higher than those of western reports, but the total duration of antipsychotic treatment was quite long. Although our study suggests the prescription dosage and duration of antipsychotic treatment decreased significantly after FDA warning in 2005, the duration of treatment was still long. Given the serious safety concerns, more effort should be made to avoid unnecessary and prolonged prescription. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922786361&doi=10.1016%2fj.jfma.2012.09.002&partnerID=40&md5=40ffa453da21fbd33aa25d00ab4a267f https://scholars.lib.ntu.edu.tw/handle/123456789/517933 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2012.09.002 | SDG/關鍵字: | quetiapine; risperidone; sulpiride; neuroleptic agent; quetiapine; risperidone; sulpiride; aged; agitation; Alzheimer disease; Article; dementia; demography; drug safety; female; human; major clinical study; male; medical record review; mixed depression and dementia; multiinfarct dementia; outpatient; physician attitude; prescription; psychosis; sample size; treatment duration; dementia; middle aged; outpatient; Psychomotor Agitation; retrospective study; severity of illness index; Taiwan; treatment outcome; very elderly; Aged; Aged, 80 and over; Antipsychotic Agents; Dementia; Female; Humans; Male; Middle Aged; Outpatients; Psychomotor Agitation; Quetiapine Fumarate; Retrospective Studies; Risperidone; Severity of Illness Index; Sulpiride; Taiwan; Treatment Outcome |
顯示於: | 醫療器材與醫學影像研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。