https://scholars.lib.ntu.edu.tw/handle/123456789/517951
標題: | The deficits on a cortical-subcortical loop of meaning processing in schizophrenia | 作者: | Chen P.-J. Fan L.-Y. TZUNG-JENG HWANG Hwu H.-G. CHIH-MIN LIU Chou T.-L. |
公開日期: | 2013 | 卷: | 24 | 期: | 3 | 起(迄)頁: | 147-151 | 來源出版物: | NeuroReport | 摘要: | Thought disorder is a core symptom of schizophrenia. However, the underlying mechanism is not well understood. Functional MRI (fMRI) was used to examine the neural mechanism of thought disorder in 20 patients with schizophrenia and 20 healthy controls during semantic judgments. Two indexes of disorganized thought were further used to evaluate individual differences in thought disturbance in the patients. Compared with the controls, the patients showed greater activation in left inferior frontal gyrus (BA45) and reduced activation in the left caudate nucleus for meaning-related pairs. Moreover, in patients, effective connectivity from Dynamic Causal Modeling showed that the modulatory effect from the caudate nucleus to the inferior frontal gyrus was weaker than that in controls, indicating a disrupted cortical-subcortical language loop for semantic processing in patients. Finally, increasing scores of disorganized thought were correlated with greater activation in the inferior frontal gyrus and weaker connection strength from the caudate nucleus to the inferior frontal gyrus. Patients with more severe disorganized symptoms might receive less efficient regulation from the caudate nucleus, resulting in increased demands for the inferior frontal gyrus to retrieve or select semantic knowledge in the cortical-subcortical circuit. Copyright ? Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873410733&doi=10.1097%2fWNR.0b013e32835df562&partnerID=40&md5=5e77b6c9dfb4484fc04d5ee9f1f0e67e https://scholars.lib.ntu.edu.tw/handle/123456789/517951 |
ISSN: | 0959-4965 | DOI: | 10.1097/WNR.0b013e32835df562 | SDG/關鍵字: | adult; article; brain function; caudate nucleus; clinical article; controlled study; female; functional magnetic resonance imaging; fusiform gyrus; human; image analysis; inferior frontal gyrus; language processing; male; mental patient; nerve cell network; priority journal; schizophrenia; semantics; thought disorder; Adult; Brain; Case-Control Studies; Female; Humans; Image Processing, Computer-Assisted; Intelligence Tests; Magnetic Resonance Imaging; Male; Mental Processes; Neural Pathways; Oxygen; Psychiatric Status Rating Scales; Schizophrenia; Statistics, Nonparametric; Young Adult |
顯示於: | 醫療器材與醫學影像研究所 |
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