https://scholars.lib.ntu.edu.tw/handle/123456789/518167
標題: | An electrospun nerve wrap comprising Bletilla striata polysaccharide with dual function for nerve regeneration and scar prevention | 作者: | Chen, Shih-Heng Chou, Pang-Yun Chen, Zhi-Yu Chuang, David Chwei-Chin SUNG-TSANG HSIEH FENG-HUEI LIN |
關鍵字: | Antiadhesion; Axon regeneration; Bletilla striata polysaccharide; Peripheral nerve regeneration; Schwann cell; Waterborne polyurethane | 公開日期: | 15-十二月-2020 | 卷: | 250 | 來源出版物: | Carbohydrate polymers | 摘要: | Peripheral nerve injuries mainly occur in the extremities and result in functional deficits, and recovery after microsurgical repair is slow (<1 mm/day) and frustrating. To improve the results of nerve repair, it is crucial to promote local Schwann cell (SC) function, neurite outgrowth, and to reduce perineural adhesion. In this study, a nerve wrap electrospun with Bletilla striata polysaccharide (BSP) and waterborne polyurethane (WPU) was designed to wrap around the repaired nerve to achieve the goal. In SC proliferation/migration tests and neurite outgrowth assay, BSP/WPU revealed considerable improvement. In rabbit sciatic nerve repair model, BSP/WPU exhibited significantly higher compound muscle action potential, muscle contraction force, and reduced perineural adhesion. The downstream fascicles of the BSP/WPU group exhibited a 50 % increase in diameter and 100 % increase in myelin thickness compared with the control group. In vitro and in vivo experiments indicated the positive effect of BSP/WPU nerve wrap on nerve regeneration. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/518167 | ISSN: | 01448617 | DOI: | 10.1016/j.carbpol.2020.116981 |
顯示於: | 解剖學暨細胞生物學科所 |
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