https://scholars.lib.ntu.edu.tw/handle/123456789/518216
標題: | Oral lesions, chronic diseases and the risk of head and neck cancer | 作者: | Li S Lee Y.-C.A Li Q Chen C.-J Hsu W.-L PEI-JEN LOU Zhu C Pan J Shen H Ma H Cai L He B Wang Y Zhou X Ji Q Zhou B Wu W Ma J Boffetta P Zhang Z.-F Dai M Hashibe M. |
公開日期: | 2015 | 出版社: | Elsevier Ltd | 卷: | 51 | 期: | 12 | 起(迄)頁: | 1082-1087 | 來源出版物: | Oral Oncology | 摘要: | Objectives The aim of our study is to explore the role of the history of oral lesions and chronic diseases on the risk of head and neck cancer in a Chinese population. Materials and methods Our case-control study included 921 head and neck cancer cases and 806 controls. We obtained medical history information by administering questionnaires to both cases and controls. We used unconditional logistic regression to estimate odds ratios for oral lesions and chronic conditions. Results Oral submucous fibrosis (OR = 24.24, 95% CI = 7.39-79.52), oral leukoplakia (OR = 4.05, 95% CI = 2.44-6.71) and repetitive dental ulcers (OR = 5.12, 95% CI = 3.17-8.28) increased the risk of HNC. Depression was associated with HNC risk when adjusted for several covariates (OR = 2.10, 95% CI = 1.06-4.15), but the association was not statistically significant after adjusting for smoking and alcohol drinking (OR = 1.53, 95% CI = 0.72-3.25). Also, the crude OR suggested an association between diabetes and HNC risk (OR = 1.51, 95% CI = 1.09-2.11), but it was not significant after adjusting for confounders. Conclusion Our study reported on strong associations between HNC risk and oral leukoplakia, oral submucous fibrosis, which is consistent with prior research. We also observed repetitive dental ulcer to be associated with HNC risk. Future studies may focus on studying the association between depression and HNC, using medical records or psychological evaluation results to get more accurate information about depression, with careful assessment of tobacco and alcohol history. ? 2015 Elsevier Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947915850&doi=10.1016%2fj.oraloncology.2015.10.014&partnerID=40&md5=fd6b82e52090eed81a67158f26316b63 https://scholars.lib.ntu.edu.tw/handle/123456789/518216 |
ISSN: | 1368-8375 | DOI: | 10.1016/j.oraloncology.2015.10.014 | SDG/關鍵字: | adult; aged; Article; cancer risk; case control study; Chinese; chronic disease; controlled study; depression; drinking behavior; female; head and neck cancer; human; leukoplakia; major clinical study; male; medical history; mouth disease; mouth lesion; mouth ulcer; priority journal; smoking; adolescent; asthma; China; chronic disease; clinical trial; Depressive Disorder; diabetes insipidus; Head and Neck Neoplasms; hypersensitivity; Leukoplakia, Oral; middle aged; multicenter study; Oral Submucous Fibrosis; Oral Ulcer; questionnaire; risk factor; statistical model; Taiwan; tuberculosis; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Asthma; Case-Control Studies; China; Chronic Disease; Depressive Disorder; Diabetes Insipidus; Female; Head and Neck Neoplasms; Humans; Hypersensitivity; Leukoplakia, Oral; Logistic Models; Male; Middle Aged; Oral Submucous Fibrosis; Oral Ulcer; Risk Factors; Smoking; Surveys and Questionnaires; Taiwan; Tuberculosis; Young Adult |
顯示於: | 醫學系 |
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