https://scholars.lib.ntu.edu.tw/handle/123456789/518244
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chou Y.-S | en_US |
dc.contributor.author | Chang C.-C | en_US |
dc.contributor.author | Chang T.-C | en_US |
dc.contributor.author | TSUNG-LIN YANG | en_US |
dc.contributor.author | Tai-Horng Young | en_US |
dc.contributor.author | PEI-JEN LOU | en_US |
dc.creator | Chou Y.-S;Chang C.-C;Chang T.-C;Yang T.-L;Young T.-H;Pei-Jen Lou | - |
dc.date.accessioned | 2020-10-27T12:04:29Z | - |
dc.date.available | 2020-10-27T12:04:29Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874628274&doi=10.1155%2f2013%2f930281&partnerID=40&md5=2eaa736a402c2ee9e6f4ebef10dde85c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/518244 | - |
dc.description.abstract | We have applied a fluorescent molecule 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC) for tumor targeting and treatment. In this study, we investigated the photo-induced antitumor effect of BMVC. In vitro cell line studies showed that BMVC significantly killed TC-1 tumor cells at light dose greater than 40 J/cm2. The fluorescence of BMVC in the tumor peaked at 3 hours and then gradually decreased to reach the control level after 24 hours. In vivo tumor treatment studies showed BMVC plus light irradiation (iPDT) significantly inhibited the tumor growth. At day 24 after tumor implantation, tumor volume was measured to be 225 ± 79 mm3, 2542 ± 181 mm3, 1533 ± 766 mm3, and 1317 ± 108 mm3 in the iPDT, control, light-only, and BMVC-only groups, respectively. Immunohistochemistry studies showed the microvascular density was significantly lower in the iPDT group. Taken together, our results demonstrated that BMVC may be a potent tumor-specific photosensitizer (PS) for PDT. ? 2013 Ya-Shuan Chou et al. | en_US |
dc.relation.ispartof | BioMed Research International | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 3,6 bis(1 methyl 4 vinylpyridinium)carbazole diiodide; antineoplastic agent; unclassified drug; 3,6 bis(1 methyl 4 vinylpyridium)carbazole diiodide; 3,6-bis(1-methyl-4-vinylpyridium)carbazole diiodide; antineoplastic agent; carbazole derivative; photosensitizing agent; pyridinium derivative; animal cell; animal experiment; animal model; antineoplastic activity; article; cancer inhibition; controlled study; density; fluorescence; immunohistochemistry; in vitro study; in vivo study; light; lung tumor; male; mouse; nonhuman; photodynamic therapy; single drug dose; tumor cell; tumor volume; animal; C57BL mouse; drug effect; human; microcirculation; neoplasm; tumor cell line; Animals; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Fluorescence; Humans; Light; Male; Mice; Mice, Inbred C57BL; Microcirculation; Neoplasms; Photosensitizing Agents; Pyridinium Compounds | - |
dc.title | Photo-induced antitumor effect of 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1155/2013/930281 | - |
dc.identifier.pmid | 23509809 | - |
dc.identifier.scopus | 2-s2.0-84874628274 | - |
dc.relation.journalvolume | 2013 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.orcid | 0000-0001-6521-8631 | - |
crisitem.author.orcid | 0000-0001-5338-4747 | - |
crisitem.author.orcid | 0000-0002-3383-8593 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。