https://scholars.lib.ntu.edu.tw/handle/123456789/518285
標題: | Transnasal endoscopy with narrow-band imaging and Lugol staining to screen patients with head and neck cancer whose condition limits oral intubation with standard endoscope (with video) | 作者: | YI-CHIA LEE CHENG-PING WANG CHIEN-CHUAN CHEN HAN-MO CHIU JENG-YUH KO PEI-JEN LOU TSUNG-LIN YANG Huang H.-Y. MING-SHIANG WU Lin J.-T. Chen, Tony Hsiu Hsi HSIU-PO WANG |
公開日期: | 2009 | 卷: | 69 | 期: | 3 | 起(迄)頁: | 408-417 | 來源出版物: | Gastrointestinal Endoscopy | 摘要: | Background: Early detection of esophageal cancer in patients with head and neck cancers may alter treatment planning and improve survival. However, standard endoscopic screening is not feasible for some patients with tumor-related airway compromise or postirradiation trismus. Objective: To evaluate a novel, sequential approach by integrating ultrathin endoscopy with narrow-band imaging and Lugol chromoendoscopy. Design: Cross-sectional study. Setting: Single center in Taiwan. Patients: Forty-four consecutive patients with transoral difficulty screened for synchronous or metachronous esophageal cancer. Main Outcome Measurements: Sensitivity, specificity, and accuracy in the detection of mucosal high-grade neoplasia or invasive cancer. Results: Fifty-four endoscopic interpretations were obtained, and 11 mucosal high-grade neoplasia and 7 invasive cancers were confirmed by histology. The mean examination time was 19.4 minutes (range 7.9-35.2 minutes), and all patients tolerated the procedure well. Sensitivity, specificity, and accuracy (with 95% CI) were 55.6% (95% CI, 33.5%-75.6%), 97.2% (95% CI, 85.8%-99.3%), and 83.3% (95% CI, 71.2%-90.9%), respectively, for standard endoscopy; 88.9% (95% CI, 66.9%-96.6%), 97.2% (95% CI, 85.8%-99.3%), and 94.4% (95% CI, 84.9%-97.9%), respectively, with the adjunct of narrow-band imaging; and 88.9% (95% CI, 66.9%-96.6%), 72.2% (95% CI, 55.9%-84.1%), and 77.8% (95% CI, 64.9%-86.8%), respectively, with the adjunct of Lugol chromoendoscopy. When we integrated all interpretations on the basis of the sequential approach, the estimated probability of false-negative findings was 1.2% (95% CI, 0.1%-4.6%). Limitations: Inherent shortcomings of ultrathin endoscopy, such as its resolution, light source, and lack of magnification. Conclusions: The use of ultrathin endoscopy in a sequential approach for multimodal detection is feasible in patients with transoral difficulty and substantially increases the detection rate of synchronous or metachronous neoplasms. ? 2009 American Society for Gastrointestinal Endoscopy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-60349099298&doi=10.1016%2fj.gie.2008.05.033&partnerID=40&md5=e91ad34f44deac2edb9c37463efe1a6b https://scholars.lib.ntu.edu.tw/handle/123456789/518285 |
ISSN: | 0016-5107 | DOI: | 10.1016/j.gie.2008.05.033 | SDG/關鍵字: | lugol; adult; article; cancer diagnosis; cancer invasion; cancer screening; chromoendoscopy; clinical article; diagnostic accuracy; endoscopy; esophagus cancer; female; head and neck cancer; histopathology; human; human tissue; intubation; laboratory diagnosis; male; narrow band imaging; priority journal; sensitivity and specificity; staining; transnasal endoscopy; Adult; Aged; Aged, 80 and over; Anal Canal; Coloring Agents; Cross-Sectional Studies; Endoscopy, Gastrointestinal; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Iodides; Male; Middle Aged; Prospective Studies; Video Recording |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。