|Title:||Association of tumor satellite distance with prognosis and contralateral neck recurrence of tongue squamous cell carcinoma||Authors:||TSUNG-LIN YANG
|Issue Date:||2008||Journal Volume:||30||Journal Issue:||5||Start page/Pages:||631-638||Source:||Head and Neck||Abstract:||
Background. The margin status is an important prognosticator for the survival of patients with tongue cancer. Although a positive margin is associated with a poor prognosis, those with clear margins do not always have good clinical outcomes. Methods. We investigated the margin status, pattern of tumor invasion (POI), and tumor satellite distance (TSD) in 119 freshly treated tongue cancers and assessed their association with the characteristics and clinical outcomes. Results. A close or clear margin and POI were not associated with overall survival. Tumor satellites occurred in 92% of tumors and were significantly associated with betel nut exposure. Patients with TSD ?0.5 mm had significantly better overall survival. Patients with TSD >0.5 mm had a higher incidence of local recurrence, shorter intervals to neck recurrence, and a higher propensity to contralateral or bilateral cervical nodal metastasis. Conclusion. TSD is associated with local recurrence, contralateral neck metastasis, and the overall survival of patients with tongue cancer. ?2008 Wiley Periodicals, Inc.
|ISSN:||1043-3074||DOI:||10.1002/hed.20758||SDG/Keyword:||adult; aged; article; cancer invasion; cancer patient; cancer recurrence; cancer surgery; cancer tissue; cervical lymph node; female; human; human tissue; lymph node metastasis; major clinical study; male; neck metastasis; overall survival; priority journal; prognosis; squamous cell carcinoma; survival rate; survival time; tongue carcinoma; Adult; Aged; Aged, 80 and over; Areca; Carcinoma, Squamous Cell; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Analysis; Taiwan; Tongue Neoplasms
|Appears in Collections:||醫學系|
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