https://scholars.lib.ntu.edu.tw/handle/123456789/519149
標題: | Effects of polymorphisms in six candidate genes on phenytoin maintenance therapy in Han Chinese patients | 作者: | Hung C.-C. Huang H.-C. Gao Y.-H. Chang W.-L. Ho J.-L. Chiou M.-H. Hsieh Y.-W. HORNG-HUEI LIOU |
公開日期: | 2012 | 卷: | 13 | 期: | 12 | 起(迄)頁: | 1339-1349 | 來源出版物: | Pharmacogenomics | 摘要: | Aim: The present study aimed to investigate the associations between variants in pharmacokinetic- and pharmacodynamic-related genes with the dosages, concentrations and concentration-dose ratios (CDRs) of phenytoin (PHT). Methods & results: Eleven genetic polymorphisms in the six candidate genes were detected in 269 epileptic patients under maintenance PHT monotherapy by real-time PCR and PCR-RFLP. Results of a bivariate analysis demonstrated that among tested polymorphisms, carriers of the variant CYP2C9*3 tended to require significantly lower maintenance PHT dosages than wild-type carriers (p < 0.0001); on the other hand, carriers of the variants CYP2C9*3 or CYP2C19*3 revealed significantly higher CDRs than wild-type carriers (p < 0.004). In a further multivariate analysis, variants in SCN1A, CYP2C9, CYP2C19 and ABCB1 genes were significantly associated with CDRs of PHT under adjustment of age, gender and epilepsy classifications (adjusted r2 = 20.07%). Conclusion: The results of present study indicated that polygenic analysis may provide useful information in PHT therapy optimization. Original submitted 3 May 2012; Revision submitted 28 June 201. ? 2012 Future Medicine Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866334122&doi=10.2217%2fpgs.12.117&partnerID=40&md5=857e4acde3bbfefa810169d83c97efb1 https://scholars.lib.ntu.edu.tw/handle/123456789/519149 |
DOI: | 10.2217/pgs.12.117 | SDG/關鍵字: | cytochrome P450 2C19; cytochrome P450 2C9; multidrug resistance protein 1; phenytoin; sodium channel Nav1.1; sodium channel Nav1.2; ABCB1 gene; ABCC2 gene; adult; article; Chinese; controlled study; CYP2C19 gene; cyp2c9 gene; epilepsy; female; gene; genetic association; genetic polymorphism; genetic variability; heterozygote; human; maintenance therapy; major clinical study; male; real time polymerase chain reaction; restriction fragment length polymorphism; SCN1A gene; SCN2A gene; Adult; Alleles; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian Continental Ancestry Group; Dose-Response Relationship, Drug; Epilepsy; Female; Genotype; Humans; Male; P-Glycoprotein; Phenytoin; Polymorphism, Genetic |
顯示於: | 醫學系 |
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