https://scholars.lib.ntu.edu.tw/handle/123456789/519153
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hung C.-C. | en_US |
dc.contributor.author | Chang W.-L. | en_US |
dc.contributor.author | Ho J.-L. | en_US |
dc.contributor.author | Tai J.J. | en_US |
dc.contributor.author | Hsieh T.-J. | en_US |
dc.contributor.author | Huang H.-C. | en_US |
dc.contributor.author | Hsieh Y.-W. | en_US |
dc.contributor.author | HORNG-HUEI LIOU | en_US |
dc.creator | Hung C.-C.;Chang W.-L.;Ho J.-L.;Tai J.J.;Hsieh T.-J.;Huang H.-C.;Hsieh Y.-W.;Horng-Huei Liou | - |
dc.date.accessioned | 2020-11-03T09:53:27Z | - |
dc.date.available | 2020-11-03T09:53:27Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862908341&doi=10.2217%2fpgs.11.141&partnerID=40&md5=5e84da860286517483f42c895defd86b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/519153 | - |
dc.description.abstract | Aim: Carbamazepine (CBZ) is one of the most widely used antiepileptic drugs. The aim of the present study is to investigate the impacts of polymorphisms in genes related to pharmacokinetic and pharmacodynamic pathways of CBZ on the large interindividual variability in dosages and concentrations. Methods & results: Genetic polymorphisms in the candidate genes were detected in 234 epileptic patients under maintenance CBZ monotherapy by real-time PCR and PCR-RFLP. Results of statistical analysis demonstrated that carriers of the variant SCN1A IVS5-91G>A and EPHX1 c.337T>C allele tended to require higher CBZ dosages and lower ln(concentration-dose ratios) than noncarriers (p < 0.0001) and the homozygous carriers also seemed to require higher CBZ dosages and lower ln(concentration-dose ratios) (p < 0.0001). In addition, the multiple regression model of concentration-dose ratio of CBZ also revealed that genetic variants in SCN1A, EPHX1 and UGT2B7 genes interactively affect the concentration-dose ratio of CBZ (adjusted r 2 = 55%). Conclusion: The present study identified genetic factors associated with CBZ therapy optimization and provided useful information for individualized CBZ therapy in epileptic patients. Further studies in larger populations are needed to confirm our results. Original submitted: 22 July 2011; Revision submitted: 27 September 201. ? 2012 Future Medicine Ltd. | - |
dc.relation.ispartof | Pharmacogenomics | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | carbamazepine; ABCB1 gene; ABCC2 gene; adult; article; blood sampling; concentration response; controlled study; DNA polymorphism; drug blood level; drug efficacy; EPHX1 gene; epilepsy; female; gene; gene frequency; gene function; gene linkage disequilibrium; genetic association; genetic variability; genotype; haplotype; heredity; human; individuality; maintenance drug dose; major clinical study; male; monotherapy; real time polymerase chain reaction; restriction fragment length polymorphism; SCN1A gene; SCN2A gene; single nucleotide polymorphism; steady state; temporal lobe epilepsy; UGT2B7 gene; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Epoxide Hydrolases; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Nerve Tissue Proteins; P-Glycoprotein; Polymorphism, Single Nucleotide; Sodium Channels | - |
dc.title | Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.2217/pgs.11.141 | - |
dc.identifier.pmid | 22188362 | - |
dc.identifier.scopus | 2-s2.0-84862908341 | - |
dc.relation.pages | 159-169 | - |
dc.relation.journalvolume | 13 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.orcid | 0000-0001-6537-5346 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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